Dynamics of cortical oxygenation during immediate adaptation to extrauterine life

Abstract The neonatal transition involves physiological modifications as a consequence of the complexity of the perinatal period. Various strategies can be used to attain the same level of postnatal cerebral oxygenation, depending on the status of the infant at birth. We evaluated such strategies by...

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Autores principales:	Léa Leroy, Mahdi Mahmoudzadeh, Jean Gondry, Arthur Foulon, Fabrice Wallois
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e022e852868843d5a56ae74551c46acd
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spelling	oai:doaj.org-article:e022e852868843d5a56ae74551c46acd2021-11-14T12:17:34ZDynamics of cortical oxygenation during immediate adaptation to extrauterine life10.1038/s41598-021-01674-92045-2322https://doaj.org/article/e022e852868843d5a56ae74551c46acd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01674-9https://doaj.org/toc/2045-2322Abstract The neonatal transition involves physiological modifications as a consequence of the complexity of the perinatal period. Various strategies can be used to attain the same level of postnatal cerebral oxygenation, depending on the status of the infant at birth. We evaluated such strategies by recording 20 full-term newborns by near-infrared spectroscopy during the first 10 min of life. The acid–base status at birth revealed two clustered profiles of cerebral oxygenation dynamics. Lower pH and base excess and higher lactate levels were associated with more rapid attainment of the 95% maximal tissue oxygenation index value. These results suggest that metabolic mechanisms drive initial cerebral oxygenation dynamics during this critical period. These results confirm the capacity of newborns to develop multiple strategies to protect the brain.Léa LeroyMahdi MahmoudzadehJean GondryArthur FoulonFabrice WalloisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Léa Leroy Mahdi Mahmoudzadeh Jean Gondry Arthur Foulon Fabrice Wallois Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
description	Abstract The neonatal transition involves physiological modifications as a consequence of the complexity of the perinatal period. Various strategies can be used to attain the same level of postnatal cerebral oxygenation, depending on the status of the infant at birth. We evaluated such strategies by recording 20 full-term newborns by near-infrared spectroscopy during the first 10 min of life. The acid–base status at birth revealed two clustered profiles of cerebral oxygenation dynamics. Lower pH and base excess and higher lactate levels were associated with more rapid attainment of the 95% maximal tissue oxygenation index value. These results suggest that metabolic mechanisms drive initial cerebral oxygenation dynamics during this critical period. These results confirm the capacity of newborns to develop multiple strategies to protect the brain.
format	article
author	Léa Leroy Mahdi Mahmoudzadeh Jean Gondry Arthur Foulon Fabrice Wallois
author_facet	Léa Leroy Mahdi Mahmoudzadeh Jean Gondry Arthur Foulon Fabrice Wallois
author_sort	Léa Leroy
title	Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
title_short	Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
title_full	Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
title_fullStr	Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
title_full_unstemmed	Dynamics of cortical oxygenation during immediate adaptation to extrauterine life
title_sort	dynamics of cortical oxygenation during immediate adaptation to extrauterine life
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e022e852868843d5a56ae74551c46acd
work_keys_str_mv	AT lealeroy dynamicsofcorticaloxygenationduringimmediateadaptationtoextrauterinelife AT mahdimahmoudzadeh dynamicsofcorticaloxygenationduringimmediateadaptationtoextrauterinelife AT jeangondry dynamicsofcorticaloxygenationduringimmediateadaptationtoextrauterinelife AT arthurfoulon dynamicsofcorticaloxygenationduringimmediateadaptationtoextrauterinelife AT fabricewallois dynamicsofcorticaloxygenationduringimmediateadaptationtoextrauterinelife
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Dynamics of cortical oxygenation during immediate adaptation to extrauterine life

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