SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair, thereby ensuring the survival of the cells.

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Autores principales:	Elisabeth Anne Adanma Obara, Diana Aguilar-Morante, Rikke Darling Rasmussen, Alex Frias, Kristoffer Vitting-Serup, Yi Chieh Lim, Kirstine Juul Elbæk, Henriette Pedersen, Lina Vardouli, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Jannick Brennum, Lucie Tuckova, Robert Strauss, Christoffel Dinant, Jiri Bartek, Petra Hamerlik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e023985afb8f4badb8ede0a95ade1510
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spelling	oai:doaj.org-article:e023985afb8f4badb8ede0a95ade15102021-12-02T18:02:08ZSPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells10.1038/s41467-020-18549-82041-1723https://doaj.org/article/e023985afb8f4badb8ede0a95ade15102020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18549-8https://doaj.org/toc/2041-1723Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair, thereby ensuring the survival of the cells.Elisabeth Anne Adanma ObaraDiana Aguilar-MoranteRikke Darling RasmussenAlex FriasKristoffer Vitting-SerupYi Chieh LimKirstine Juul ElbækHenriette PedersenLina VardouliKamilla Ellermann JensenJane Skjoth-RasmussenJannick BrennumLucie TuckovaRobert StraussChristoffel DinantJiri BartekPetra HamerlikNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisabeth Anne Adanma Obara Diana Aguilar-Morante Rikke Darling Rasmussen Alex Frias Kristoffer Vitting-Serup Yi Chieh Lim Kirstine Juul Elbæk Henriette Pedersen Lina Vardouli Kamilla Ellermann Jensen Jane Skjoth-Rasmussen Jannick Brennum Lucie Tuckova Robert Strauss Christoffel Dinant Jiri Bartek Petra Hamerlik SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
description	Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA repair, thereby ensuring the survival of the cells.
format	article
author	Elisabeth Anne Adanma Obara Diana Aguilar-Morante Rikke Darling Rasmussen Alex Frias Kristoffer Vitting-Serup Yi Chieh Lim Kirstine Juul Elbæk Henriette Pedersen Lina Vardouli Kamilla Ellermann Jensen Jane Skjoth-Rasmussen Jannick Brennum Lucie Tuckova Robert Strauss Christoffel Dinant Jiri Bartek Petra Hamerlik
author_facet	Elisabeth Anne Adanma Obara Diana Aguilar-Morante Rikke Darling Rasmussen Alex Frias Kristoffer Vitting-Serup Yi Chieh Lim Kirstine Juul Elbæk Henriette Pedersen Lina Vardouli Kamilla Ellermann Jensen Jane Skjoth-Rasmussen Jannick Brennum Lucie Tuckova Robert Strauss Christoffel Dinant Jiri Bartek Petra Hamerlik
author_sort	Elisabeth Anne Adanma Obara
title	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
title_short	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
title_full	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
title_fullStr	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
title_full_unstemmed	SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
title_sort	spt6-driven error-free dna repair safeguards genomic stability of glioblastoma cancer stem-like cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e023985afb8f4badb8ede0a95ade1510
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

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