ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.

We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical so...

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Autores principales:	Staš Bevc, Janez Konc, Jure Stojan, Milan Hodošček, Matej Penca, Matej Praprotnik, Dušanka Janežič
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e027394a2db2484893dde545c2a8c00b
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spelling	oai:doaj.org-article:e027394a2db2484893dde545c2a8c00b2021-11-18T06:49:56ZENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.1932-620310.1371/journal.pone.0022265https://doaj.org/article/e027394a2db2484893dde545c2a8c00b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21818304/?tool=EBIhttps://doaj.org/toc/1932-6203We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be used for routine tests in enzyme kinetics. It is freely available as a web tool, at http://enzo.cmm.ki.si.Staš BevcJanez KoncJure StojanMilan HodoščekMatej PencaMatej PraprotnikDušanka JanežičPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22265 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Staš Bevc Janez Konc Jure Stojan Milan Hodošček Matej Penca Matej Praprotnik Dušanka Janežič ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
description	We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be used for routine tests in enzyme kinetics. It is freely available as a web tool, at http://enzo.cmm.ki.si.
format	article
author	Staš Bevc Janez Konc Jure Stojan Milan Hodošček Matej Penca Matej Praprotnik Dušanka Janežič
author_facet	Staš Bevc Janez Konc Jure Stojan Milan Hodošček Matej Penca Matej Praprotnik Dušanka Janežič
author_sort	Staš Bevc
title	ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
title_short	ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
title_full	ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
title_fullStr	ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
title_full_unstemmed	ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
title_sort	enzo: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e027394a2db2484893dde545c2a8c00b
work_keys_str_mv	AT stasbevc enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT janezkonc enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT jurestojan enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT milanhodoscek enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT matejpenca enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT matejpraprotnik enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions AT dusankajanezic enzoawebtoolforderivationandevaluationofkineticmodelsofenzymecatalyzedreactions
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ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.

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