Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior.

Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and controlling pacemaker n...

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Bibliographic Details
Main Authors: Adam Seluzicki, Matthieu Flourakis, Elzbieta Kula-Eversole, Luoying Zhang, Valerie Kilman, Ravi Allada
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
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Online Access:https://doaj.org/article/e027b6f8b3b74e09adc61462ecd7d78b
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