The gut microbiome is associated with brain structure and function in schizophrenia

Abstract The effect of the gut microbiome on the central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about the relationship between the gut microbiome and brain structure and function is still very limited. Here, we used 16S rRNA se...

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Autores principales:	Shijia Li, Jie Song, Pengfei Ke, Lingyin Kong, Bingye Lei, Jing Zhou, Yuanyuan Huang, Hehua Li, Guixiang Li, Jun Chen, Xiaobo Li, Zhiming Xiang, Yuping Ning, Fengchun Wu, Kai Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e0289ebf425943f99d1a84b485d83f5a
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spelling	oai:doaj.org-article:e0289ebf425943f99d1a84b485d83f5a2021-12-02T15:37:58ZThe gut microbiome is associated with brain structure and function in schizophrenia10.1038/s41598-021-89166-82045-2322https://doaj.org/article/e0289ebf425943f99d1a84b485d83f5a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89166-8https://doaj.org/toc/2045-2322Abstract The effect of the gut microbiome on the central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about the relationship between the gut microbiome and brain structure and function is still very limited. Here, we used 16S rRNA sequencing with structural magnetic resonance imaging (sMRI) and resting-state functional (rs-fMRI) to investigate differences in fecal microbiota between 38 patients with schizophrenia (SZ) and 38 demographically matched normal controls (NCs) and explored whether such differences were associated with brain structure and function. At the genus level, we found that the relative abundance of Ruminococcus and Roseburia was significantly lower, whereas the abundance of Veillonella was significantly higher in SZ patients than in NCs. Additionally, the analysis of MRI data revealed that several brain regions showed significantly lower gray matter volume (GMV) and regional homogeneity (ReHo) but significantly higher amplitude of low-frequency fluctuation in SZ patients than in NCs. Moreover, the alpha diversity of the gut microbiota showed a strong linear relationship with the values of both GMV and ReHo. In SZ patients, the ReHo indexes in the right STC (r = − 0.35, p = 0.031, FDR corrected p = 0.039), the left cuneus (r = − 0.33, p = 0.044, FDR corrected p = 0.053) and the right MTC (r = − 0.34, p = 0.03, FDR corrected p = 0.052) were negatively correlated with the abundance of the genus Roseburia. Our results suggest that the potential role of the gut microbiome in SZ is related to alterations in brain structure and function. This study provides insights into the underlying neuropathology of SZ.Shijia LiJie SongPengfei KeLingyin KongBingye LeiJing ZhouYuanyuan HuangHehua LiGuixiang LiJun ChenXiaobo LiZhiming XiangYuping NingFengchun WuKai WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shijia Li Jie Song Pengfei Ke Lingyin Kong Bingye Lei Jing Zhou Yuanyuan Huang Hehua Li Guixiang Li Jun Chen Xiaobo Li Zhiming Xiang Yuping Ning Fengchun Wu Kai Wu The gut microbiome is associated with brain structure and function in schizophrenia
description	Abstract The effect of the gut microbiome on the central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about the relationship between the gut microbiome and brain structure and function is still very limited. Here, we used 16S rRNA sequencing with structural magnetic resonance imaging (sMRI) and resting-state functional (rs-fMRI) to investigate differences in fecal microbiota between 38 patients with schizophrenia (SZ) and 38 demographically matched normal controls (NCs) and explored whether such differences were associated with brain structure and function. At the genus level, we found that the relative abundance of Ruminococcus and Roseburia was significantly lower, whereas the abundance of Veillonella was significantly higher in SZ patients than in NCs. Additionally, the analysis of MRI data revealed that several brain regions showed significantly lower gray matter volume (GMV) and regional homogeneity (ReHo) but significantly higher amplitude of low-frequency fluctuation in SZ patients than in NCs. Moreover, the alpha diversity of the gut microbiota showed a strong linear relationship with the values of both GMV and ReHo. In SZ patients, the ReHo indexes in the right STC (r = − 0.35, p = 0.031, FDR corrected p = 0.039), the left cuneus (r = − 0.33, p = 0.044, FDR corrected p = 0.053) and the right MTC (r = − 0.34, p = 0.03, FDR corrected p = 0.052) were negatively correlated with the abundance of the genus Roseburia. Our results suggest that the potential role of the gut microbiome in SZ is related to alterations in brain structure and function. This study provides insights into the underlying neuropathology of SZ.
format	article
author	Shijia Li Jie Song Pengfei Ke Lingyin Kong Bingye Lei Jing Zhou Yuanyuan Huang Hehua Li Guixiang Li Jun Chen Xiaobo Li Zhiming Xiang Yuping Ning Fengchun Wu Kai Wu
author_facet	Shijia Li Jie Song Pengfei Ke Lingyin Kong Bingye Lei Jing Zhou Yuanyuan Huang Hehua Li Guixiang Li Jun Chen Xiaobo Li Zhiming Xiang Yuping Ning Fengchun Wu Kai Wu
author_sort	Shijia Li
title	The gut microbiome is associated with brain structure and function in schizophrenia
title_short	The gut microbiome is associated with brain structure and function in schizophrenia
title_full	The gut microbiome is associated with brain structure and function in schizophrenia
title_fullStr	The gut microbiome is associated with brain structure and function in schizophrenia
title_full_unstemmed	The gut microbiome is associated with brain structure and function in schizophrenia
title_sort	gut microbiome is associated with brain structure and function in schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0289ebf425943f99d1a84b485d83f5a
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The gut microbiome is associated with brain structure and function in schizophrenia

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