RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis

RIPK1 regulates inflammation and cell death and is inhibited by phosphorylation on numerous residues. Here, the authors use a CRISPR whole genome screen to identify that protein phosphatase 1 regulatory subunit 3G regulates RIPK1 apoptotic and necroptotic activity as well as inflammation.

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Autores principales:	Jingchun Du, Yougui Xiang, Hua Liu, Shuzhen Liu, Ashwani Kumar, Chao Xing, Zhigao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e02974a731ee4b789a9a4b1c6903b322
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spelling	oai:doaj.org-article:e02974a731ee4b789a9a4b1c6903b3222021-12-05T12:22:10ZRIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis10.1038/s41467-021-27367-52041-1723https://doaj.org/article/e02974a731ee4b789a9a4b1c6903b3222021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27367-5https://doaj.org/toc/2041-1723RIPK1 regulates inflammation and cell death and is inhibited by phosphorylation on numerous residues. Here, the authors use a CRISPR whole genome screen to identify that protein phosphatase 1 regulatory subunit 3G regulates RIPK1 apoptotic and necroptotic activity as well as inflammation.Jingchun DuYougui XiangHua LiuShuzhen LiuAshwani KumarChao XingZhigao WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingchun Du Yougui Xiang Hua Liu Shuzhen Liu Ashwani Kumar Chao Xing Zhigao Wang RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
description	RIPK1 regulates inflammation and cell death and is inhibited by phosphorylation on numerous residues. Here, the authors use a CRISPR whole genome screen to identify that protein phosphatase 1 regulatory subunit 3G regulates RIPK1 apoptotic and necroptotic activity as well as inflammation.
format	article
author	Jingchun Du Yougui Xiang Hua Liu Shuzhen Liu Ashwani Kumar Chao Xing Zhigao Wang
author_facet	Jingchun Du Yougui Xiang Hua Liu Shuzhen Liu Ashwani Kumar Chao Xing Zhigao Wang
author_sort	Jingchun Du
title	RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
title_short	RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
title_full	RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
title_fullStr	RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
title_full_unstemmed	RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
title_sort	ripk1 dephosphorylation and kinase activation by ppp1r3g/pp1γ promote apoptosis and necroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e02974a731ee4b789a9a4b1c6903b322
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RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis

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