The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz

Introduction: Celiac disease results from the interaction of gluten, the immune system, and genetic and environmental factors, which is diagnosed via clinical symptomsincludingweight loss, steatorrhea, and malnutrition. It is usually presented in children who have malnutrition and failure to thrive,...

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Autores principales:	Naser Honar, Negar Yazdani, Maryam Ataollahi, Mohammad Hadi Imanieh, Zohreh Karamizadeh
Formato:	article
Lenguaje:	FA
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	celiac disease child obesity prevalence serology Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e029b4f740164f8a9b518046d534cb89
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spelling	oai:doaj.org-article:e029b4f740164f8a9b518046d534cb892021-12-02T19:53:19ZThe Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz2322-433910.30476/smsj.2021.88110.1174https://doaj.org/article/e029b4f740164f8a9b518046d534cb892021-05-01T00:00:00Zhttps://smsj.sums.ac.ir/article_47651_04eff02e281431e87ac102f2bbc24ee2.pdfhttps://doaj.org/toc/2322-4339Introduction: Celiac disease results from the interaction of gluten, the immune system, and genetic and environmental factors, which is diagnosed via clinical symptomsincludingweight loss, steatorrhea, and malnutrition. It is usually presented in children who have malnutrition and failure to thrive, but it has been recently reported in some obese children. Since nowadays screening of high-risk/susceptible groups has been emphasized, this study aimed to evaluate the frequency of serologic celiac disease in obese children. Methods: This cross-sectional study was conducted on 104obese children who referred to the Endocrine Clinic of Shiraz University of Medical Sciences, Shiraz, Iran in 2016. Data were collected using a questionnaire through face to face interviews. To measure Anti TTG IgA and total IgA Ab, 5 ml blood sample was taken. Data analysis was done using SPSS version 18. Results: The mean age and BMI of the participants were 10.33±2.39 and 24.71±4.78, respectively, 65% of whom were girls. In this study, five patients (4.9%) had positive Anti TTG IgA, 80% of whom had reported positive gastrointestinal symptoms. The statistical tests suggested a positive and significant correlation between gastrointestinal symptoms and Anti TTG IgA. Conclusion: Compared to 2% prevalence of serological TTG Anti in our community, a 5% prevalence Anti TTG IgA in obese children may indicate that there is an increased risk of potential celiac in obese children compared to the normal population. Therefore, it is recommended to screen obese children for celiac disease periodically and perform endoscopy and biopsy in the cases with persistence of anti-TTG.Naser HonarNegar YazdaniMaryam AtaollahiMohammad Hadi ImaniehZohreh KaramizadehShiraz University of Medical Sciencesarticleceliac diseasechildobesityprevalenceserologyMedicineRMedicine (General)R5-920FAمجله علوم پزشکی صدرا, Vol 9, Iss 2, Pp 145-152 (2021)
institution	DOAJ
collection	DOAJ
language	FA
topic	celiac disease child obesity prevalence serology Medicine R Medicine (General) R5-920
spellingShingle	celiac disease child obesity prevalence serology Medicine R Medicine (General) R5-920 Naser Honar Negar Yazdani Maryam Ataollahi Mohammad Hadi Imanieh Zohreh Karamizadeh The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
description	Introduction: Celiac disease results from the interaction of gluten, the immune system, and genetic and environmental factors, which is diagnosed via clinical symptomsincludingweight loss, steatorrhea, and malnutrition. It is usually presented in children who have malnutrition and failure to thrive, but it has been recently reported in some obese children. Since nowadays screening of high-risk/susceptible groups has been emphasized, this study aimed to evaluate the frequency of serologic celiac disease in obese children. Methods: This cross-sectional study was conducted on 104obese children who referred to the Endocrine Clinic of Shiraz University of Medical Sciences, Shiraz, Iran in 2016. Data were collected using a questionnaire through face to face interviews. To measure Anti TTG IgA and total IgA Ab, 5 ml blood sample was taken. Data analysis was done using SPSS version 18. Results: The mean age and BMI of the participants were 10.33±2.39 and 24.71±4.78, respectively, 65% of whom were girls. In this study, five patients (4.9%) had positive Anti TTG IgA, 80% of whom had reported positive gastrointestinal symptoms. The statistical tests suggested a positive and significant correlation between gastrointestinal symptoms and Anti TTG IgA. Conclusion: Compared to 2% prevalence of serological TTG Anti in our community, a 5% prevalence Anti TTG IgA in obese children may indicate that there is an increased risk of potential celiac in obese children compared to the normal population. Therefore, it is recommended to screen obese children for celiac disease periodically and perform endoscopy and biopsy in the cases with persistence of anti-TTG.
format	article
author	Naser Honar Negar Yazdani Maryam Ataollahi Mohammad Hadi Imanieh Zohreh Karamizadeh
author_facet	Naser Honar Negar Yazdani Maryam Ataollahi Mohammad Hadi Imanieh Zohreh Karamizadeh
author_sort	Naser Honar
title	The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
title_short	The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
title_full	The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
title_fullStr	The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
title_full_unstemmed	The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz
title_sort	frequency of serologic celiac disease in obese children referring to endocrine clinic in shiraz
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/e029b4f740164f8a9b518046d534cb89
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The Frequency of Serologic Celiac Disease in Obese Children Referring to Endocrine Clinic in Shiraz

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