Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat

BACKGROUND AND OBJECTIVE: It has been reported that selective sigma receptor agonists have neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion. Neuroprotective effects of sigma receptor agonists in the embolic model of stroke have not yet been repo...

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Autores principales:	M Allahtavakoli, A Shamsizadeh, N Jarrott
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	sigma agonist embolic model of cerebral ischemia neuroprotection Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e02bd02687314bca8e3b466de5e4481d
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spelling	oai:doaj.org-article:e02bd02687314bca8e3b466de5e4481d2021-11-10T08:56:42ZEffect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat1561-41072251-7170https://doaj.org/article/e02bd02687314bca8e3b466de5e4481d2011-07-01T00:00:00Zhttp://jbums.org/article-1-3841-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: It has been reported that selective sigma receptor agonists have neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion. Neuroprotective effects of sigma receptor agonists in the embolic model of stroke have not yet been reported which were investigated in the current study.METHODS: In this experiment, 24 male Wistar rats (250-300 gr) were randomly categorized to 3 groups including control, treatment and sham. Embolic ischemia was induced by injection of 20 mm (5 µl) natural clot into MCA and in sham-operated animals 5 µl saline was injected. Animals then were treated with the sigma-1 receptor agonist PRE-084 (10mg/kg i.p) vehicle (saline) 3h and 24h after stroke. Infarct volume and neurological deficits were conducted at 48h after stroke induction and compared.FINDINGS: Infarct volume in PRE-084 treated or control groups were 11.8±1.65 and 26.45±2.19, respectively (p<0.001). Treatment with PRE-084 also improved neurologic motor and sensory behaviours (p<0.001).CONCLUSION: The findings of the present study suggest the neuroprotective effects of sigma-1 receptor agonists in the embolic model of stroke, which is very resemble to ischemic stroke in clinic.M AllahtavakoliA ShamsizadehN JarrottBabol University of Medical Sciencesarticlesigma agonistembolic model of cerebral ischemianeuroprotectionMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 40-47 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	sigma agonist embolic model of cerebral ischemia neuroprotection Medicine R Medicine (General) R5-920
spellingShingle	sigma agonist embolic model of cerebral ischemia neuroprotection Medicine R Medicine (General) R5-920 M Allahtavakoli A Shamsizadeh N Jarrott Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
description	BACKGROUND AND OBJECTIVE: It has been reported that selective sigma receptor agonists have neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion. Neuroprotective effects of sigma receptor agonists in the embolic model of stroke have not yet been reported which were investigated in the current study.METHODS: In this experiment, 24 male Wistar rats (250-300 gr) were randomly categorized to 3 groups including control, treatment and sham. Embolic ischemia was induced by injection of 20 mm (5 µl) natural clot into MCA and in sham-operated animals 5 µl saline was injected. Animals then were treated with the sigma-1 receptor agonist PRE-084 (10mg/kg i.p) vehicle (saline) 3h and 24h after stroke. Infarct volume and neurological deficits were conducted at 48h after stroke induction and compared.FINDINGS: Infarct volume in PRE-084 treated or control groups were 11.8±1.65 and 26.45±2.19, respectively (p<0.001). Treatment with PRE-084 also improved neurologic motor and sensory behaviours (p<0.001).CONCLUSION: The findings of the present study suggest the neuroprotective effects of sigma-1 receptor agonists in the embolic model of stroke, which is very resemble to ischemic stroke in clinic.
format	article
author	M Allahtavakoli A Shamsizadeh N Jarrott
author_facet	M Allahtavakoli A Shamsizadeh N Jarrott
author_sort	M Allahtavakoli
title	Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
title_short	Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
title_full	Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
title_fullStr	Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
title_full_unstemmed	Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat
title_sort	effect of delayed stimulation of sigma-1 receptor on embolic model of cerebral ischemia in rat
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/e02bd02687314bca8e3b466de5e4481d
work_keys_str_mv	AT mallahtavakoli effectofdelayedstimulationofsigma1receptoronembolicmodelofcerebralischemiainrat AT ashamsizadeh effectofdelayedstimulationofsigma1receptoronembolicmodelofcerebralischemiainrat AT njarrott effectofdelayedstimulationofsigma1receptoronembolicmodelofcerebralischemiainrat
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Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat

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