Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

The development of peptide-based vaccines for treating human neurodegenerative diseases has been the eventual aim of many research endeavors, although no active immunotherapies have been approved for clinical use till now. A typical example of such endeavors is the effort to develop vaccines for Alz...

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Autores principales:	Vyronia Vassilakopoulou, Chrysoula-Evangelia Karachaliou, Alexandra Evangelou, Christos Zikos, Evangelia Livaniou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vaccines neurodegenerative diseases Alzheimer’s disease beta-amyloid peptide tau protein α-synuclein Medicine R
Acceso en línea:	https://doaj.org/article/e02da4c886c148378405191022f9b062
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spelling	oai:doaj.org-article:e02da4c886c148378405191022f9b0622021-11-25T19:10:52ZPeptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives10.3390/vaccines91112782076-393Xhttps://doaj.org/article/e02da4c886c148378405191022f9b0622021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1278https://doaj.org/toc/2076-393XThe development of peptide-based vaccines for treating human neurodegenerative diseases has been the eventual aim of many research endeavors, although no active immunotherapies have been approved for clinical use till now. A typical example of such endeavors is the effort to develop vaccines for Alzheimer’s disease based on the beta-amyloid peptide, which continues to be intensively investigated despite previous setbacks. In this paper, recent developments in peptide-based vaccines which target beta-amyloid as well as tau protein and α-synuclein are presented. Particular focus has been directed toward peptide epitopes and formulation systems selected/developed and employed to enhance vaccine efficacy and safety. Results from both, human clinical trials and animal preclinical studies conducted mainly in transgenic mice have been included. Future perspectives on the topic are also briefly discussed.Vyronia VassilakopoulouChrysoula-Evangelia KarachaliouAlexandra EvangelouChristos ZikosEvangelia LivaniouMDPI AGarticlevaccinesneurodegenerative diseasesAlzheimer’s diseasebeta-amyloid peptidetau proteinα-synucleinMedicineRENVaccines, Vol 9, Iss 1278, p 1278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccines neurodegenerative diseases Alzheimer’s disease beta-amyloid peptide tau protein α-synuclein Medicine R
spellingShingle	vaccines neurodegenerative diseases Alzheimer’s disease beta-amyloid peptide tau protein α-synuclein Medicine R Vyronia Vassilakopoulou Chrysoula-Evangelia Karachaliou Alexandra Evangelou Christos Zikos Evangelia Livaniou Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
description	The development of peptide-based vaccines for treating human neurodegenerative diseases has been the eventual aim of many research endeavors, although no active immunotherapies have been approved for clinical use till now. A typical example of such endeavors is the effort to develop vaccines for Alzheimer’s disease based on the beta-amyloid peptide, which continues to be intensively investigated despite previous setbacks. In this paper, recent developments in peptide-based vaccines which target beta-amyloid as well as tau protein and α-synuclein are presented. Particular focus has been directed toward peptide epitopes and formulation systems selected/developed and employed to enhance vaccine efficacy and safety. Results from both, human clinical trials and animal preclinical studies conducted mainly in transgenic mice have been included. Future perspectives on the topic are also briefly discussed.
format	article
author	Vyronia Vassilakopoulou Chrysoula-Evangelia Karachaliou Alexandra Evangelou Christos Zikos Evangelia Livaniou
author_facet	Vyronia Vassilakopoulou Chrysoula-Evangelia Karachaliou Alexandra Evangelou Christos Zikos Evangelia Livaniou
author_sort	Vyronia Vassilakopoulou
title	Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
title_short	Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
title_full	Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
title_fullStr	Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
title_full_unstemmed	Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives
title_sort	peptide-based vaccines for neurodegenerative diseases: recent endeavors and future perspectives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e02da4c886c148378405191022f9b062
work_keys_str_mv	AT vyroniavassilakopoulou peptidebasedvaccinesforneurodegenerativediseasesrecentendeavorsandfutureperspectives AT chrysoulaevangeliakarachaliou peptidebasedvaccinesforneurodegenerativediseasesrecentendeavorsandfutureperspectives AT alexandraevangelou peptidebasedvaccinesforneurodegenerativediseasesrecentendeavorsandfutureperspectives AT christoszikos peptidebasedvaccinesforneurodegenerativediseasesrecentendeavorsandfutureperspectives AT evangelialivaniou peptidebasedvaccinesforneurodegenerativediseasesrecentendeavorsandfutureperspectives
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Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

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