Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review

Background: Many of the known coronaviruses cause a wide range of respiratory infections in humans, and the novel coronavirus is no exception to this rule. Although no drug has yet been discovered to prevent or treat this disease, chloroquine (CQ) and hydroxychloroquine (HCQ)have been widely used in...

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Autores principales:	Kavous Shahsavarinia, Morteza Ghojazadeh, Sarvin Sanaie, Leila Vahedi, Mahta Ahmadpour, Ata Mahmoodpoor, Hassan Soleimanpour
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	hydroxychloroquine chloroquine covid-19 mortality Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/e03019ba87324b6ba24312606790b0cf
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spelling	oai:doaj.org-article:e03019ba87324b6ba24312606790b0cf2021-11-29T05:51:55ZClinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review2383-288610.34172/PS.2021.66https://doaj.org/article/e03019ba87324b6ba24312606790b0cf2021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-481.pdfhttps://doaj.org/toc/2383-2886Background: Many of the known coronaviruses cause a wide range of respiratory infections in humans, and the novel coronavirus is no exception to this rule. Although no drug has yet been discovered to prevent or treat this disease, chloroquine (CQ) and hydroxychloroquine (HCQ)have been widely used in studies showing different results. Methods: The present study is an umbrella study. The search was conducted for the articles published from January 2020 to November 2020 using the keywords ("COVID-19" OR "SARSCoV-2" AND "Hydroxychloroquine" OR "Chloroquine" AND "Systematic Review" OR"Metanalysis"). This study was limited to human samples and systematic reviews with or without meta-analysis. The quality of the articles was also evaluated independently by two researchers. Results: To evaluate the clinical efficacy of HCQ and CQ, a total of 176 papers and 643569 cases ranging from patients with mild pneumonia to intubated critically ill patients were evaluated. Finally, 8 studies were included. Conclusion: There are conflicting results regarding HCQ or CQ efficacy and safety in the systematic reviews. More evidence is needed to confirm whether these drugs are useful in COVID-19 infection, and their usage as the standard care cannot be recommended based on the majority of the studies included in this umbrella review.Kavous ShahsavariniaMorteza GhojazadehSarvin SanaieLeila VahediMahta AhmadpourAta MahmoodpoorHassan SoleimanpourTabriz University of Medical Sciencesarticlehydroxychloroquinechloroquinecovid-19mortalityPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 481-488 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroxychloroquine chloroquine covid-19 mortality Pharmacy and materia medica RS1-441
spellingShingle	hydroxychloroquine chloroquine covid-19 mortality Pharmacy and materia medica RS1-441 Kavous Shahsavarinia Morteza Ghojazadeh Sarvin Sanaie Leila Vahedi Mahta Ahmadpour Ata Mahmoodpoor Hassan Soleimanpour Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
description	Background: Many of the known coronaviruses cause a wide range of respiratory infections in humans, and the novel coronavirus is no exception to this rule. Although no drug has yet been discovered to prevent or treat this disease, chloroquine (CQ) and hydroxychloroquine (HCQ)have been widely used in studies showing different results. Methods: The present study is an umbrella study. The search was conducted for the articles published from January 2020 to November 2020 using the keywords ("COVID-19" OR "SARSCoV-2" AND "Hydroxychloroquine" OR "Chloroquine" AND "Systematic Review" OR"Metanalysis"). This study was limited to human samples and systematic reviews with or without meta-analysis. The quality of the articles was also evaluated independently by two researchers. Results: To evaluate the clinical efficacy of HCQ and CQ, a total of 176 papers and 643569 cases ranging from patients with mild pneumonia to intubated critically ill patients were evaluated. Finally, 8 studies were included. Conclusion: There are conflicting results regarding HCQ or CQ efficacy and safety in the systematic reviews. More evidence is needed to confirm whether these drugs are useful in COVID-19 infection, and their usage as the standard care cannot be recommended based on the majority of the studies included in this umbrella review.
format	article
author	Kavous Shahsavarinia Morteza Ghojazadeh Sarvin Sanaie Leila Vahedi Mahta Ahmadpour Ata Mahmoodpoor Hassan Soleimanpour
author_facet	Kavous Shahsavarinia Morteza Ghojazadeh Sarvin Sanaie Leila Vahedi Mahta Ahmadpour Ata Mahmoodpoor Hassan Soleimanpour
author_sort	Kavous Shahsavarinia
title	Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
title_short	Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
title_full	Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
title_fullStr	Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
title_full_unstemmed	Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review
title_sort	clinical efficacy of hydroxychloroquine or chloroquine in patients with covid-19: an umbrella review
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/e03019ba87324b6ba24312606790b0cf
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Clinical Efficacy of Hydroxychloroquine or Chloroquine in Patients with COVID-19: An Umbrella Review

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