Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis

Alzheimer’s disease is known as a most common dementia disorder in the world. The famous hypothesis about the cause of this disease is beta-amyloid (Aβ ) accumulation in the brain. There is a widespread neuroinflammation in the patient’s brain, leading to neuronal apoptosis and brain atrophy. Curcum...

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Autores principales:	Shima Mehrabadi, Azam Alinaghpour, Elham Zahedi
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2021
Materias:	alzheimer’s disease beta-amyloid curcumin meta-analysis Medicine R
Acceso en línea:	https://doaj.org/article/e03478bbf6d74470a60bcd1636a79b0c
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spelling	oai:doaj.org-article:e03478bbf6d74470a60bcd1636a79b0c2021-11-16T10:50:48ZEffect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis2383-18712383-209610.34172/icnj.2021.13https://doaj.org/article/e03478bbf6d74470a60bcd1636a79b0c2021-03-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/33819/26860https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096Alzheimer’s disease is known as a most common dementia disorder in the world. The famous hypothesis about the cause of this disease is beta-amyloid (Aβ ) accumulation in the brain. There is a widespread neuroinflammation in the patient’s brain, leading to neuronal apoptosis and brain atrophy. Curcumin is a well-known anti-inflammation and anti-oxidant ingredient. It can easily cross the blood-brain barrier. There are controversial results about the effects of curcumin on Aβ clearance and metabolism in Alzheimer’s disease and the elderly. The aim of this meta-analysis and systematic review was to review the effect of curcumin on Aβ clearance in clinical studies. We performed a systematic review and meta-analysis on the three randomized clinical trials (RCTs) and one pilot study that assessed the effect of curcumin on Aβ plasma level in Alzheimer’s disease. For this purpose, we searched PubMed and Scopus databases up to December 2020. Our result showed there was no significant change in serum Aβ level (weighted mean difference [WMD]: 5.3, 95% CI: 0.78-9.97) following curcumin consumption in patients with Alzheimer’s disease. Further clinical trials should be done to evaluate the effects of curcumin in Aβ level in Alzheimer’s disease.Shima MehrabadiAzam AlinaghpourElham ZahediShahid Beheshti University of Medical Sciencesarticlealzheimer’s diseasebeta-amyloidcurcuminmeta-analysisMedicineRENInternational Clinical Neuroscience Journal, Vol 8, Iss 2, Pp 55-59 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alzheimer’s disease beta-amyloid curcumin meta-analysis Medicine R
spellingShingle	alzheimer’s disease beta-amyloid curcumin meta-analysis Medicine R Shima Mehrabadi Azam Alinaghpour Elham Zahedi Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
description	Alzheimer’s disease is known as a most common dementia disorder in the world. The famous hypothesis about the cause of this disease is beta-amyloid (Aβ ) accumulation in the brain. There is a widespread neuroinflammation in the patient’s brain, leading to neuronal apoptosis and brain atrophy. Curcumin is a well-known anti-inflammation and anti-oxidant ingredient. It can easily cross the blood-brain barrier. There are controversial results about the effects of curcumin on Aβ clearance and metabolism in Alzheimer’s disease and the elderly. The aim of this meta-analysis and systematic review was to review the effect of curcumin on Aβ clearance in clinical studies. We performed a systematic review and meta-analysis on the three randomized clinical trials (RCTs) and one pilot study that assessed the effect of curcumin on Aβ plasma level in Alzheimer’s disease. For this purpose, we searched PubMed and Scopus databases up to December 2020. Our result showed there was no significant change in serum Aβ level (weighted mean difference [WMD]: 5.3, 95% CI: 0.78-9.97) following curcumin consumption in patients with Alzheimer’s disease. Further clinical trials should be done to evaluate the effects of curcumin in Aβ level in Alzheimer’s disease.
format	article
author	Shima Mehrabadi Azam Alinaghpour Elham Zahedi
author_facet	Shima Mehrabadi Azam Alinaghpour Elham Zahedi
author_sort	Shima Mehrabadi
title	Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
title_short	Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
title_full	Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
title_fullStr	Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
title_full_unstemmed	Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis
title_sort	effect of curcumin on beta-amyloid plasma level in alzheimer disease: a systematic review and meta-analysis
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/e03478bbf6d74470a60bcd1636a79b0c
work_keys_str_mv	AT shimamehrabadi effectofcurcuminonbetaamyloidplasmalevelinalzheimerdiseaseasystematicreviewandmetaanalysis AT azamalinaghpour effectofcurcuminonbetaamyloidplasmalevelinalzheimerdiseaseasystematicreviewandmetaanalysis AT elhamzahedi effectofcurcuminonbetaamyloidplasmalevelinalzheimerdiseaseasystematicreviewandmetaanalysis
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Effect of Curcumin on Beta-Amyloid Plasma Level in Alzheimer Disease: A Systematic Review and Meta-analysis

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