Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia

Abstract Oral contraceptive (OC) effects on the brain have gained increasing interest, but are highly controversial. Previous studies suggest that OC users have larger hippocampi, parahippocampi, fusiform gyri and Cerebelli. Preliminary evidence from one of those studies even suggests an effect of p...

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Autores principales:	Belinda Pletzer, TiAnni Harris, Esmeralda Hidalgo-Lopez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e038658134234c68abf2604ed163d18e
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spelling	oai:doaj.org-article:e038658134234c68abf2604ed163d18e2021-12-02T15:09:22ZPrevious contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia10.1038/s41598-019-47446-42045-2322https://doaj.org/article/e038658134234c68abf2604ed163d18e2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47446-4https://doaj.org/toc/2045-2322Abstract Oral contraceptive (OC) effects on the brain have gained increasing interest, but are highly controversial. Previous studies suggest that OC users have larger hippocampi, parahippocampi, fusiform gyri and Cerebelli. Preliminary evidence from one of those studies even suggests an effect of previous contraceptive use on the hippocampi of women who are not current users of OCs. Furthermore, more recent studies postulate an involvement of previous OC treatment in later development of mood disorders. To address the question whether previous OC treatment affects women’s brain structure later in life, high resolution structural images were obtained from 131 naturally cycling women. Among them, 52 women had never used OC before, 52 had previously used one OC for a continuous time period and 27 had previously used multiple contraceptives. The groups did not differ in gray matter volumes. Since endogenous sex hormones modulate gray matter volumes of the hippocampus and basal ganglia along the menstrual cycle, we hypothesize effects of OC use on these areas. Specifically, we hypothesize that a longer duration of previous OC treatment is related to larger hippocampi and larger basal ganglia. Indeed we found the duration of previous OC use to be positively correlated to hippocampal and basal ganglia volumes bilaterally. For the hippocampus, but not for the basal ganglia, this association disappeared after controlling for the time since discontinuation. These results suggest that for the hippocampus, but not for the basal ganglia, effects of previous contraceptive treatment are reversed after a time period comparable to treatment duration. These data question the immediate reversibility of OC effects on brain structure. Accordingly, some changes in the brain due to long-term contraceptive use, while subtle, may be long-lasting.Belinda PletzerTiAnni HarrisEsmeralda Hidalgo-LopezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Belinda Pletzer TiAnni Harris Esmeralda Hidalgo-Lopez Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
description	Abstract Oral contraceptive (OC) effects on the brain have gained increasing interest, but are highly controversial. Previous studies suggest that OC users have larger hippocampi, parahippocampi, fusiform gyri and Cerebelli. Preliminary evidence from one of those studies even suggests an effect of previous contraceptive use on the hippocampi of women who are not current users of OCs. Furthermore, more recent studies postulate an involvement of previous OC treatment in later development of mood disorders. To address the question whether previous OC treatment affects women’s brain structure later in life, high resolution structural images were obtained from 131 naturally cycling women. Among them, 52 women had never used OC before, 52 had previously used one OC for a continuous time period and 27 had previously used multiple contraceptives. The groups did not differ in gray matter volumes. Since endogenous sex hormones modulate gray matter volumes of the hippocampus and basal ganglia along the menstrual cycle, we hypothesize effects of OC use on these areas. Specifically, we hypothesize that a longer duration of previous OC treatment is related to larger hippocampi and larger basal ganglia. Indeed we found the duration of previous OC use to be positively correlated to hippocampal and basal ganglia volumes bilaterally. For the hippocampus, but not for the basal ganglia, this association disappeared after controlling for the time since discontinuation. These results suggest that for the hippocampus, but not for the basal ganglia, effects of previous contraceptive treatment are reversed after a time period comparable to treatment duration. These data question the immediate reversibility of OC effects on brain structure. Accordingly, some changes in the brain due to long-term contraceptive use, while subtle, may be long-lasting.
format	article
author	Belinda Pletzer TiAnni Harris Esmeralda Hidalgo-Lopez
author_facet	Belinda Pletzer TiAnni Harris Esmeralda Hidalgo-Lopez
author_sort	Belinda Pletzer
title	Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
title_short	Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
title_full	Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
title_fullStr	Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
title_full_unstemmed	Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
title_sort	previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e038658134234c68abf2604ed163d18e
work_keys_str_mv	AT belindapletzer previouscontraceptivetreatmentrelatestogreymattervolumesinthehippocampusandbasalganglia AT tianniharris previouscontraceptivetreatmentrelatestogreymattervolumesinthehippocampusandbasalganglia AT esmeraldahidalgolopez previouscontraceptivetreatmentrelatestogreymattervolumesinthehippocampusandbasalganglia
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Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia

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