Lack of beta-arrestin signaling in the absence of active G proteins
Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators.
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Nature Portfolio
2018
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oai:doaj.org-article:e038d4ec42a84fe0b5f232ccf68a180d2021-12-02T17:31:26ZLack of beta-arrestin signaling in the absence of active G proteins10.1038/s41467-017-02661-32041-1723https://doaj.org/article/e038d4ec42a84fe0b5f232ccf68a180d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02661-3https://doaj.org/toc/2041-1723Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators.Manuel GrundmannNicole MertenDavide MalfaciniAsuka InouePhilip PreisKatharina SimonNelly RüttigerNicole ZieglerTobias BenkelNina Katharina SchmittSatoru IshidaInes MüllerRaphael ReherKouki KawakamiAyumi InoueUlrike RickToni KühlDiana ImhofJunken AokiGabriele M. KönigCarsten HoffmannJesus GomezaJürgen WessEvi KostenisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Manuel Grundmann Nicole Merten Davide Malfacini Asuka Inoue Philip Preis Katharina Simon Nelly Rüttiger Nicole Ziegler Tobias Benkel Nina Katharina Schmitt Satoru Ishida Ines Müller Raphael Reher Kouki Kawakami Ayumi Inoue Ulrike Rick Toni Kühl Diana Imhof Junken Aoki Gabriele M. König Carsten Hoffmann Jesus Gomeza Jürgen Wess Evi Kostenis Lack of beta-arrestin signaling in the absence of active G proteins |
| description |
Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators. |
| format |
article |
| author |
Manuel Grundmann Nicole Merten Davide Malfacini Asuka Inoue Philip Preis Katharina Simon Nelly Rüttiger Nicole Ziegler Tobias Benkel Nina Katharina Schmitt Satoru Ishida Ines Müller Raphael Reher Kouki Kawakami Ayumi Inoue Ulrike Rick Toni Kühl Diana Imhof Junken Aoki Gabriele M. König Carsten Hoffmann Jesus Gomeza Jürgen Wess Evi Kostenis |
| author_facet |
Manuel Grundmann Nicole Merten Davide Malfacini Asuka Inoue Philip Preis Katharina Simon Nelly Rüttiger Nicole Ziegler Tobias Benkel Nina Katharina Schmitt Satoru Ishida Ines Müller Raphael Reher Kouki Kawakami Ayumi Inoue Ulrike Rick Toni Kühl Diana Imhof Junken Aoki Gabriele M. König Carsten Hoffmann Jesus Gomeza Jürgen Wess Evi Kostenis |
| author_sort |
Manuel Grundmann |
| title |
Lack of beta-arrestin signaling in the absence of active G proteins |
| title_short |
Lack of beta-arrestin signaling in the absence of active G proteins |
| title_full |
Lack of beta-arrestin signaling in the absence of active G proteins |
| title_fullStr |
Lack of beta-arrestin signaling in the absence of active G proteins |
| title_full_unstemmed |
Lack of beta-arrestin signaling in the absence of active G proteins |
| title_sort |
lack of beta-arrestin signaling in the absence of active g proteins |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e038d4ec42a84fe0b5f232ccf68a180d |
| work_keys_str_mv |
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| _version_ |
1718380644265885696 |