Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia

Abstract Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ellen G. Wann, Anirudh Wodeyar, Ramesh Srinivasan, Ron D. Frostig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e03aada51d4840e08e7d1d55ba945bde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e03aada51d4840e08e7d1d55ba945bde
record_format	dspace
spelling	oai:doaj.org-article:e03aada51d4840e08e7d1d55ba945bde2021-12-02T11:43:58ZRapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia10.1038/s41598-020-78179-42045-2322https://doaj.org/article/e03aada51d4840e08e7d1d55ba945bde2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78179-4https://doaj.org/toc/2045-2322Abstract Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal activity signatures of ischemia. Using a 32-microelectrode array spanning the depth of cortex, electrophysiological recordings generated for the first time a continuous spatiotemporal profile of local field potentials (LFP) and multi-unit activity (MUA) before (baseline) and directly after (0–5 h) distal, permanent MCA occlusion (pMCAo) in a rat model. Although evoked activity persisted for hours after pMCAo with minor differences from baseline, spatiotemporal analyses of spontaneous activity revealed that LFP became spatially and temporally synchronized regardless of cortical depth within minutes after pMCAo and extended over large parts of cortex. Such enhanced post-ischemic synchrony was found to be driven by increased bursts of low multi-frequency oscillations and continued throughout the acute ischemic period whereas synchrony measures minimally changed over the same recording period in surgical sham controls. EEG recordings of a similar frequency range have been applied to successfully predict stroke damage and recovery, suggesting clear clinical relevance for our rat model.Ellen G. WannAnirudh WodeyarRamesh SrinivasanRon D. FrostigNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ellen G. Wann Anirudh Wodeyar Ramesh Srinivasan Ron D. Frostig Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
description	Abstract Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal activity signatures of ischemia. Using a 32-microelectrode array spanning the depth of cortex, electrophysiological recordings generated for the first time a continuous spatiotemporal profile of local field potentials (LFP) and multi-unit activity (MUA) before (baseline) and directly after (0–5 h) distal, permanent MCA occlusion (pMCAo) in a rat model. Although evoked activity persisted for hours after pMCAo with minor differences from baseline, spatiotemporal analyses of spontaneous activity revealed that LFP became spatially and temporally synchronized regardless of cortical depth within minutes after pMCAo and extended over large parts of cortex. Such enhanced post-ischemic synchrony was found to be driven by increased bursts of low multi-frequency oscillations and continued throughout the acute ischemic period whereas synchrony measures minimally changed over the same recording period in surgical sham controls. EEG recordings of a similar frequency range have been applied to successfully predict stroke damage and recovery, suggesting clear clinical relevance for our rat model.
format	article
author	Ellen G. Wann Anirudh Wodeyar Ramesh Srinivasan Ron D. Frostig
author_facet	Ellen G. Wann Anirudh Wodeyar Ramesh Srinivasan Ron D. Frostig
author_sort	Ellen G. Wann
title	Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
title_short	Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
title_full	Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
title_fullStr	Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
title_full_unstemmed	Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia
title_sort	rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute mca focal ischemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e03aada51d4840e08e7d1d55ba945bde
work_keys_str_mv	AT ellengwann rapiddevelopmentofstrongpersistentspatiotemporallyextensivecorticalsynchronyandunderlyingoscillationsfollowingacutemcafocalischemia AT anirudhwodeyar rapiddevelopmentofstrongpersistentspatiotemporallyextensivecorticalsynchronyandunderlyingoscillationsfollowingacutemcafocalischemia AT rameshsrinivasan rapiddevelopmentofstrongpersistentspatiotemporallyextensivecorticalsynchronyandunderlyingoscillationsfollowingacutemcafocalischemia AT rondfrostig rapiddevelopmentofstrongpersistentspatiotemporallyextensivecorticalsynchronyandunderlyingoscillationsfollowingacutemcafocalischemia
_version_	1718395315204128768

Rapid development of strong, persistent, spatiotemporally extensive cortical synchrony and underlying oscillations following acute MCA focal ischemia

Ejemplares similares