Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam

Rang Ngoc Nguyen,1,2 Quang Chanh Ton,2 Quang Hien Tran,2 Thi Kieu Linh Nguyen2 1Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam; 2Women and Children Hospital of an Giang, An Giang, VietnamCorrespondence: Rang Ngoc Nguyen Tel +84 913106404Email nguyenngocrang@g...

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Autores principales:	Nguyen RN, Ton QC, Tran QH, Nguyen TKL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hiv-exposed infants antiretrovirals mtct of hiv vietnam Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e03b097725914068a0d5114f6cf7cd08
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spelling	oai:doaj.org-article:e03b097725914068a0d5114f6cf7cd082021-12-02T10:33:52ZMother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam1179-1373https://doaj.org/article/e03b097725914068a0d5114f6cf7cd082020-07-01T00:00:00Zhttps://www.dovepress.com/mother-to-child-transmission-of-hiv-and-its-predictors-among-hiv-expos-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Rang Ngoc Nguyen,1,2 Quang Chanh Ton,2 Quang Hien Tran,2 Thi Kieu Linh Nguyen2 1Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam; 2Women and Children Hospital of an Giang, An Giang, VietnamCorrespondence: Rang Ngoc Nguyen Tel +84 913106404Email nguyenngocrang@gmail.comBackground: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) is decreasing worldwide; however, achieving the MTCT elimination target of 2% by 2020 and 0% by 2030 is challenging in resource-limited countries. The purpose of this study is to determine the evolution of the HIV transmission rate in infants from 2007 to 2018 and to identify the risk factors of HIV transmission among HIV-exposed infants in Vietnam.Patients and Methods: A prospective cohort study of 608 HIV-exposed infants was conducted at the Pediatric Outpatient Clinic (pOPC) of the Women and Children Hospital of An Giang, Vietnam between September 2007 and December 2019. A follow-up registration book was used to collect data, which were entered into Microsoft Excel and analyzed by SPSS version 22.0. Both bivariate and multivariate analyses were carried out to identify associations.Results: A total of 608 HIV-exposed infant were enrolled in the study, of which 472 were included in the final analysis. The median age of infants at enrollment to follow-up was 6.3 weeks (interquartile range [IQR]=6.0– 6.9 weeks). A total of 42 infants out of 472 were infected with HIV, giving an overall MTCT rate of 8.9% (95% confidence interval (CI)=6.4– 12.0). The transmission rate decreased from 27.9% in 2007 to 0% in 2018. Absence of maternal ARV (antiretrovirals) intervention before or during pregnancy (AOR=40.6, 95% CI=5.5– 308) and absence of ARV prophylaxis for HIV-exposed infants (AOR=3.4, 95% CI=1.1– 10.3) were significantly and independently associated with MTCT of HIV in this study.Conclusion: There is a significant progress on the reduction of MTCT rate in An Giang, Vietnam. Absence of ART interventions for mothers and infants are significant factors associated with HIV transmission. Providing free ARV and increasing the coverage of ARV intervention for pregnant women are keys for reducing the MTCT rate in the future.Keywords: HIV-exposed infants, antiretrovirals, MTCT of HIV, VietnamNguyen RNTon QCTran QHNguyen TKLDove Medical Pressarticlehiv-exposed infantsantiretroviralsmtct of hivvietnamImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 253-261 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv-exposed infants antiretrovirals mtct of hiv vietnam Immunologic diseases. Allergy RC581-607
spellingShingle	hiv-exposed infants antiretrovirals mtct of hiv vietnam Immunologic diseases. Allergy RC581-607 Nguyen RN Ton QC Tran QH Nguyen TKL Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
description	Rang Ngoc Nguyen,1,2 Quang Chanh Ton,2 Quang Hien Tran,2 Thi Kieu Linh Nguyen2 1Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam; 2Women and Children Hospital of an Giang, An Giang, VietnamCorrespondence: Rang Ngoc Nguyen Tel +84 913106404Email nguyenngocrang@gmail.comBackground: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) is decreasing worldwide; however, achieving the MTCT elimination target of 2% by 2020 and 0% by 2030 is challenging in resource-limited countries. The purpose of this study is to determine the evolution of the HIV transmission rate in infants from 2007 to 2018 and to identify the risk factors of HIV transmission among HIV-exposed infants in Vietnam.Patients and Methods: A prospective cohort study of 608 HIV-exposed infants was conducted at the Pediatric Outpatient Clinic (pOPC) of the Women and Children Hospital of An Giang, Vietnam between September 2007 and December 2019. A follow-up registration book was used to collect data, which were entered into Microsoft Excel and analyzed by SPSS version 22.0. Both bivariate and multivariate analyses were carried out to identify associations.Results: A total of 608 HIV-exposed infant were enrolled in the study, of which 472 were included in the final analysis. The median age of infants at enrollment to follow-up was 6.3 weeks (interquartile range [IQR]=6.0– 6.9 weeks). A total of 42 infants out of 472 were infected with HIV, giving an overall MTCT rate of 8.9% (95% confidence interval (CI)=6.4– 12.0). The transmission rate decreased from 27.9% in 2007 to 0% in 2018. Absence of maternal ARV (antiretrovirals) intervention before or during pregnancy (AOR=40.6, 95% CI=5.5– 308) and absence of ARV prophylaxis for HIV-exposed infants (AOR=3.4, 95% CI=1.1– 10.3) were significantly and independently associated with MTCT of HIV in this study.Conclusion: There is a significant progress on the reduction of MTCT rate in An Giang, Vietnam. Absence of ART interventions for mothers and infants are significant factors associated with HIV transmission. Providing free ARV and increasing the coverage of ARV intervention for pregnant women are keys for reducing the MTCT rate in the future.Keywords: HIV-exposed infants, antiretrovirals, MTCT of HIV, Vietnam
format	article
author	Nguyen RN Ton QC Tran QH Nguyen TKL
author_facet	Nguyen RN Ton QC Tran QH Nguyen TKL
author_sort	Nguyen RN
title	Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
title_short	Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
title_full	Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
title_fullStr	Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
title_full_unstemmed	Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam
title_sort	mother-to-child transmission of hiv and its predictors among hiv-exposed infants at an outpatient clinic for hiv/aids in vietnam
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e03b097725914068a0d5114f6cf7cd08
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Mother-to-Child Transmission of HIV and Its Predictors Among HIV-Exposed Infants at an Outpatient Clinic for HIV/AIDS in Vietnam

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