Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Abstract This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC dur...

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Autores principales:	Simona Parisse, Flaminia Ferri, Marzia Persichetti, Monica Mischitelli, Aurelio Abbatecola, Michele Di Martino, Quirino Lai, Sara Carnevale, Pierleone Lucatelli, Mario Bezzi, Massimo Rossi, Adriano De Santis, Alessandra Spagnoli, Stefano Ginanni Corradini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e03b74014f5a49358ccf27a3938f28e7
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spelling	oai:doaj.org-article:e03b74014f5a49358ccf27a3938f28e72021-12-02T16:24:56ZLow serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients10.1038/s41598-021-94509-62045-2322https://doaj.org/article/e03b74014f5a49358ccf27a3938f28e72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94509-6https://doaj.org/toc/2045-2322Abstract This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels.Simona ParisseFlaminia FerriMarzia PersichettiMonica MischitelliAurelio AbbatecolaMichele Di MartinoQuirino LaiSara CarnevalePierleone LucatelliMario BezziMassimo RossiAdriano De SantisAlessandra SpagnoliStefano Ginanni CorradiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simona Parisse Flaminia Ferri Marzia Persichetti Monica Mischitelli Aurelio Abbatecola Michele Di Martino Quirino Lai Sara Carnevale Pierleone Lucatelli Mario Bezzi Massimo Rossi Adriano De Santis Alessandra Spagnoli Stefano Ginanni Corradini Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
description	Abstract This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels.
format	article
author	Simona Parisse Flaminia Ferri Marzia Persichetti Monica Mischitelli Aurelio Abbatecola Michele Di Martino Quirino Lai Sara Carnevale Pierleone Lucatelli Mario Bezzi Massimo Rossi Adriano De Santis Alessandra Spagnoli Stefano Ginanni Corradini
author_facet	Simona Parisse Flaminia Ferri Marzia Persichetti Monica Mischitelli Aurelio Abbatecola Michele Di Martino Quirino Lai Sara Carnevale Pierleone Lucatelli Mario Bezzi Massimo Rossi Adriano De Santis Alessandra Spagnoli Stefano Ginanni Corradini
author_sort	Simona Parisse
title	Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
title_short	Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
title_full	Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
title_fullStr	Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
title_full_unstemmed	Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
title_sort	low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e03b74014f5a49358ccf27a3938f28e7
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Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

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