Residential radon and brain tumour incidence in a Danish cohort.

<h4>Background</h4>Increased brain tumour incidence over recent decades may reflect improved diagnostic methods and clinical practice, but remain unexplained. Although estimated doses are low a relationship between radon and brain tumours may exist.<h4>Objective</h4>To invest...

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Autores principales:	Elvira V Bräuner, Zorana J Andersen, Claus E Andersen, Camilla Pedersen, Peter Gravesen, Kaare Ulbak, Ole Hertel, Steffen Loft, Ole Raaschou-Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e03eb44a4dc74dd1bc2bdba2757319e9
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spelling	oai:doaj.org-article:e03eb44a4dc74dd1bc2bdba2757319e92021-11-18T08:55:04ZResidential radon and brain tumour incidence in a Danish cohort.1932-620310.1371/journal.pone.0074435https://doaj.org/article/e03eb44a4dc74dd1bc2bdba2757319e92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24066143/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Increased brain tumour incidence over recent decades may reflect improved diagnostic methods and clinical practice, but remain unexplained. Although estimated doses are low a relationship between radon and brain tumours may exist.<h4>Objective</h4>To investigate the long-term effect of exposure to residential radon on the risk of primary brain tumour in a prospective Danish cohort.<h4>Methods</h4>During 1993-1997 we recruited 57,053 persons. We followed each cohort member for cancer occurrence from enrolment until 31 December 2009, identifying 121 primary brain tumour cases. We traced residential addresses from 1 January 1971 until 31 December 2009 and calculated radon concentrations at each address using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate-ratios (IRR) and 95% confidence intervals (CI) for the risk of primary brain tumours associated with residential radon exposure with adjustment for age, sex, occupation, fruit and vegetable consumption and traffic-related air pollution. Effect modification by air pollution was assessed.<h4>Results</h4>Median estimated radon was 40.5 Bq/m(3). The adjusted IRR for primary brain tumour associated with each 100 Bq/m(3) increment in average residential radon levels was 1.96 (95% CI: 1.07; 3.58) and this was exposure-dependently higher over the four radon exposure quartiles. This association was not modified by air pollution.<h4>Conclusions</h4>We found significant associations and exposure-response patterns between long-term residential radon exposure radon in a general population and risk of primary brain tumours, adding new knowledge to this field. This finding could be chance and needs to be challenged in future studies.Elvira V BräunerZorana J AndersenClaus E AndersenCamilla PedersenPeter GravesenKaare UlbakOle HertelSteffen LoftOle Raaschou-NielsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74435 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elvira V Bräuner Zorana J Andersen Claus E Andersen Camilla Pedersen Peter Gravesen Kaare Ulbak Ole Hertel Steffen Loft Ole Raaschou-Nielsen Residential radon and brain tumour incidence in a Danish cohort.
description	<h4>Background</h4>Increased brain tumour incidence over recent decades may reflect improved diagnostic methods and clinical practice, but remain unexplained. Although estimated doses are low a relationship between radon and brain tumours may exist.<h4>Objective</h4>To investigate the long-term effect of exposure to residential radon on the risk of primary brain tumour in a prospective Danish cohort.<h4>Methods</h4>During 1993-1997 we recruited 57,053 persons. We followed each cohort member for cancer occurrence from enrolment until 31 December 2009, identifying 121 primary brain tumour cases. We traced residential addresses from 1 January 1971 until 31 December 2009 and calculated radon concentrations at each address using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate-ratios (IRR) and 95% confidence intervals (CI) for the risk of primary brain tumours associated with residential radon exposure with adjustment for age, sex, occupation, fruit and vegetable consumption and traffic-related air pollution. Effect modification by air pollution was assessed.<h4>Results</h4>Median estimated radon was 40.5 Bq/m(3). The adjusted IRR for primary brain tumour associated with each 100 Bq/m(3) increment in average residential radon levels was 1.96 (95% CI: 1.07; 3.58) and this was exposure-dependently higher over the four radon exposure quartiles. This association was not modified by air pollution.<h4>Conclusions</h4>We found significant associations and exposure-response patterns between long-term residential radon exposure radon in a general population and risk of primary brain tumours, adding new knowledge to this field. This finding could be chance and needs to be challenged in future studies.
format	article
author	Elvira V Bräuner Zorana J Andersen Claus E Andersen Camilla Pedersen Peter Gravesen Kaare Ulbak Ole Hertel Steffen Loft Ole Raaschou-Nielsen
author_facet	Elvira V Bräuner Zorana J Andersen Claus E Andersen Camilla Pedersen Peter Gravesen Kaare Ulbak Ole Hertel Steffen Loft Ole Raaschou-Nielsen
author_sort	Elvira V Bräuner
title	Residential radon and brain tumour incidence in a Danish cohort.
title_short	Residential radon and brain tumour incidence in a Danish cohort.
title_full	Residential radon and brain tumour incidence in a Danish cohort.
title_fullStr	Residential radon and brain tumour incidence in a Danish cohort.
title_full_unstemmed	Residential radon and brain tumour incidence in a Danish cohort.
title_sort	residential radon and brain tumour incidence in a danish cohort.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e03eb44a4dc74dd1bc2bdba2757319e9
work_keys_str_mv	AT elviravbrauner residentialradonandbraintumourincidenceinadanishcohort AT zoranajandersen residentialradonandbraintumourincidenceinadanishcohort AT clauseandersen residentialradonandbraintumourincidenceinadanishcohort AT camillapedersen residentialradonandbraintumourincidenceinadanishcohort AT petergravesen residentialradonandbraintumourincidenceinadanishcohort AT kaareulbak residentialradonandbraintumourincidenceinadanishcohort AT olehertel residentialradonandbraintumourincidenceinadanishcohort AT steffenloft residentialradonandbraintumourincidenceinadanishcohort AT oleraaschounielsen residentialradonandbraintumourincidenceinadanishcohort
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Residential radon and brain tumour incidence in a Danish cohort.

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