Chrysanthemum indicum Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells

Oxidative stress-mediated neuronal damage is associated with the pathogenesis and development of neurodegenerative diseases. Chrysanthemum indicum has antioxidant properties. However, the neuroprotective effects and the cellular mechanism of C. indicum ethanol e...

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Autores principales:	Yun Hee Jeong, Tae In Kim, You-Chang Oh, Jin Yeul Ma
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Chrysanthemum indicum</i> neuroprotective effects antioxidant nuclear factor erythroid 2-related factor 2 tropomyosin-related kinase receptor B protein kinase B Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e03f10563ec74182a6d8341213cd90af
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spelling	oai:doaj.org-article:e03f10563ec74182a6d8341213cd90af2021-11-25T18:33:13Z<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells10.3390/nu131136902072-6643https://doaj.org/article/e03f10563ec74182a6d8341213cd90af2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3690https://doaj.org/toc/2072-6643Oxidative stress-mediated neuronal damage is associated with the pathogenesis and development of neurodegenerative diseases. <i>Chrysanthemum indicum</i> has antioxidant properties. However, the neuroprotective effects and the cellular mechanism of <i>C. indicum</i> ethanol extract (CIE) against oxidative damage in hippocampal neuronal cells have not been clearly elucidated. Therefore, this study investigated whether CIE has protective effects against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced oxidative toxicity in HT22 cells. CIE pretreatment significantly improved neuronal cell viability. Moreover, the formation of intracellular reactive oxygen species and apoptotic bodies, and mitochondrial depolarization were significantly reduced in HT22 cells with H<sub>2</sub>O<sub>2</sub>-induced oxidative toxicity. Furthermore, CIE increased the phosphorylation of tropomyosin-related kinase receptor B (TrkB), protein kinase B (Akt), cAMP response element-binding protein, the expression of brain-derived neurotrophic factor, antioxidant enzymes, and the nuclear translocation of nuclear factor erythroid 2-related factor 2 by activating the TrkB/Akt signaling pathway. In contrast, the addition of K252a, a TrkB inhibitor, or MK-2206, an Akt-selective inhibitor, reduced the neuroprotective and antioxidant effects of CIE. Taken together; CIE exhibits neuroprotective and antioxidant effects against oxidative damage. Therefore, it can be a potential agent for treating oxidative stress-related neurodegenerative diseases.Yun Hee JeongTae In KimYou-Chang OhJin Yeul MaMDPI AGarticle<i>Chrysanthemum indicum</i>neuroprotective effectsantioxidantnuclear factor erythroid 2-related factor 2tropomyosin-related kinase receptor Bprotein kinase BNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3690, p 3690 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Chrysanthemum indicum</i> neuroprotective effects antioxidant nuclear factor erythroid 2-related factor 2 tropomyosin-related kinase receptor B protein kinase B Nutrition. Foods and food supply TX341-641
spellingShingle	<i>Chrysanthemum indicum</i> neuroprotective effects antioxidant nuclear factor erythroid 2-related factor 2 tropomyosin-related kinase receptor B protein kinase B Nutrition. Foods and food supply TX341-641 Yun Hee Jeong Tae In Kim You-Chang Oh Jin Yeul Ma <i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
description	Oxidative stress-mediated neuronal damage is associated with the pathogenesis and development of neurodegenerative diseases. <i>Chrysanthemum indicum</i> has antioxidant properties. However, the neuroprotective effects and the cellular mechanism of <i>C. indicum</i> ethanol extract (CIE) against oxidative damage in hippocampal neuronal cells have not been clearly elucidated. Therefore, this study investigated whether CIE has protective effects against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced oxidative toxicity in HT22 cells. CIE pretreatment significantly improved neuronal cell viability. Moreover, the formation of intracellular reactive oxygen species and apoptotic bodies, and mitochondrial depolarization were significantly reduced in HT22 cells with H<sub>2</sub>O<sub>2</sub>-induced oxidative toxicity. Furthermore, CIE increased the phosphorylation of tropomyosin-related kinase receptor B (TrkB), protein kinase B (Akt), cAMP response element-binding protein, the expression of brain-derived neurotrophic factor, antioxidant enzymes, and the nuclear translocation of nuclear factor erythroid 2-related factor 2 by activating the TrkB/Akt signaling pathway. In contrast, the addition of K252a, a TrkB inhibitor, or MK-2206, an Akt-selective inhibitor, reduced the neuroprotective and antioxidant effects of CIE. Taken together; CIE exhibits neuroprotective and antioxidant effects against oxidative damage. Therefore, it can be a potential agent for treating oxidative stress-related neurodegenerative diseases.
format	article
author	Yun Hee Jeong Tae In Kim You-Chang Oh Jin Yeul Ma
author_facet	Yun Hee Jeong Tae In Kim You-Chang Oh Jin Yeul Ma
author_sort	Yun Hee Jeong
title	<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
title_short	<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
title_full	<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
title_fullStr	<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
title_full_unstemmed	<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells
title_sort	<i>chrysanthemum indicum</i> prevents hydrogen peroxide-induced neurotoxicity by activating the trkb/akt signaling pathway in hippocampal neuronal cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e03f10563ec74182a6d8341213cd90af
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<i>Chrysanthemum indicum</i> Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells

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