Haploinsufficiency of akt1 prolongs the lifespan of mice.
There is increasing evidence that nutrient-sensing machinery is critically involved in the regulation of aging. The insulin/insulin-like growth factor-1 signaling pathway is the best-characterized pathway with an influence on longevity in a variety of organisms, ranging from yeast to rodents. Reduce...
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Main Authors: | Aika Nojima, Masakatsu Yamashita, Yohko Yoshida, Ippei Shimizu, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Naoaki Ishii, Tohru Minamino |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Subjects: | |
Online Access: | https://doaj.org/article/e04105dc4ed44a10b29229bac99f9b10 |
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