Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages

Abstract Macrophages serve as viral reservoirs due to their resistance to apoptosis and HIV-cytopathic effects. We have previously shown that inhibitor of apoptosis proteins (IAPs) confer resistance to HIV-Vpr-induced apoptosis in normal macrophages. Herein, we show that second mitochondrial activat...

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Autores principales: Ramon Edwin Caballero, Simon Xin Min Dong, Niranjala Gajanayaka, Hamza Ali, Edana Cassol, William D. Cameron, Robert Korneluk, Michel J. Tremblay, Jonathan Angel, Ashok Kumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/e042e27adcd1469d86cdf4e6c7ba50c4
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