A genome-wide survey of genetic instability by transposition in Drosophila hybrids.

Hybridization between species is a genomic instability factor involved in increasing mutation rate and new chromosomal rearrangements. Evidence of a relationship between interspecific hybridization and transposable element mobilization has been reported in different organisms, but most studies are u...

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Autores principales:	Doris Vela, Antonio Fontdevila, Cristina Vieira, María Pilar García Guerreiro
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e04635ed4eb94e44948246986aa18421
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spelling	oai:doaj.org-article:e04635ed4eb94e44948246986aa184212021-11-18T08:31:47ZA genome-wide survey of genetic instability by transposition in Drosophila hybrids.1932-620310.1371/journal.pone.0088992https://doaj.org/article/e04635ed4eb94e44948246986aa184212014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586475/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hybridization between species is a genomic instability factor involved in increasing mutation rate and new chromosomal rearrangements. Evidence of a relationship between interspecific hybridization and transposable element mobilization has been reported in different organisms, but most studies are usually performed with particular TEs and do not discuss the real effect of hybridization on the whole genome. We have therefore studied whole genome instability of Drosophila interspecific hybrids, looking for the presence of new AFLP markers in hybrids. A high percentage (27-90%) of the instability markers detected corresponds to TEs belonging to classes I and II. Moreover, three transposable elements (Osvaldo, Helena and Galileo) representative of different families, showed an overall increase of transposition rate in hybrids compared to parental species. This research confirms the hypothesis that hybridization induces genomic instability by transposition bursts and suggests that genomic stress by transposition could contribute to a relaxation of mechanisms controlling TEs in the Drosophila genome.Doris VelaAntonio FontdevilaCristina VieiraMaría Pilar García GuerreiroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88992 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Doris Vela Antonio Fontdevila Cristina Vieira María Pilar García Guerreiro A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
description	Hybridization between species is a genomic instability factor involved in increasing mutation rate and new chromosomal rearrangements. Evidence of a relationship between interspecific hybridization and transposable element mobilization has been reported in different organisms, but most studies are usually performed with particular TEs and do not discuss the real effect of hybridization on the whole genome. We have therefore studied whole genome instability of Drosophila interspecific hybrids, looking for the presence of new AFLP markers in hybrids. A high percentage (27-90%) of the instability markers detected corresponds to TEs belonging to classes I and II. Moreover, three transposable elements (Osvaldo, Helena and Galileo) representative of different families, showed an overall increase of transposition rate in hybrids compared to parental species. This research confirms the hypothesis that hybridization induces genomic instability by transposition bursts and suggests that genomic stress by transposition could contribute to a relaxation of mechanisms controlling TEs in the Drosophila genome.
format	article
author	Doris Vela Antonio Fontdevila Cristina Vieira María Pilar García Guerreiro
author_facet	Doris Vela Antonio Fontdevila Cristina Vieira María Pilar García Guerreiro
author_sort	Doris Vela
title	A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
title_short	A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
title_full	A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
title_fullStr	A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
title_full_unstemmed	A genome-wide survey of genetic instability by transposition in Drosophila hybrids.
title_sort	genome-wide survey of genetic instability by transposition in drosophila hybrids.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e04635ed4eb94e44948246986aa18421
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A genome-wide survey of genetic instability by transposition in Drosophila hybrids.

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