Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high...

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Autores principales:	Haisong Liu, Ronghui Li, Hsin-Kai Liao, Zheying Min, Chao Wang, Yang Yu, Lei Shi, Jiameng Dan, Alberto Hayek, Llanos Martinez Martinez, Estrella Nuñez Delicado, Juan Carlos Izpisua Belmonte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0538b6a302e489391b9de003c23bba8
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spelling	oai:doaj.org-article:e0538b6a302e489391b9de003c23bba82021-12-02T17:34:34ZChemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells10.1038/s41467-021-23525-x2041-1723https://doaj.org/article/e0538b6a302e489391b9de003c23bba82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23525-xhttps://doaj.org/toc/2041-1723Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.Haisong LiuRonghui LiHsin-Kai LiaoZheying MinChao WangYang YuLei ShiJiameng DanAlberto HayekLlanos Martinez MartinezEstrella Nuñez DelicadoJuan Carlos Izpisua BelmonteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
description	Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy. Here the authors perform stage-wise chemical screening to develop an improved protocol for hPSC differentiation to functional pancreatic beta cells at high efficiency.
format	article
author	Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte
author_facet	Haisong Liu Ronghui Li Hsin-Kai Liao Zheying Min Chao Wang Yang Yu Lei Shi Jiameng Dan Alberto Hayek Llanos Martinez Martinez Estrella Nuñez Delicado Juan Carlos Izpisua Belmonte
author_sort	Haisong Liu
title	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_short	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_full	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_fullStr	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_full_unstemmed	Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells
title_sort	chemical combinations potentiate human pluripotent stem cell-derived 3d pancreatic progenitor clusters toward functional β cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e0538b6a302e489391b9de003c23bba8
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Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

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