Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Phospho-MurNAc-pentapeptide translocase (MraY) is a bacterial integral membrane enzyme that is essential for peptidoglycan biosynthesis. Here the authors present the crystal structures of MraY from Aquifex aeolicus bound to caprazamycin, capuramycin and mureidomycin and discuss the implications for...

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Autores principales:	Ellene H. Mashalidis, Benjamin Kaeser, Yuma Terasawa, Akira Katsuyama, Do-Yeon Kwon, Kiyoun Lee, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0558f6d0eab41fcbb345629cf908792
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spelling	oai:doaj.org-article:e0558f6d0eab41fcbb345629cf9087922021-12-02T15:35:53ZChemical logic of MraY inhibition by antibacterial nucleoside natural products10.1038/s41467-019-10957-92041-1723https://doaj.org/article/e0558f6d0eab41fcbb345629cf9087922019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10957-9https://doaj.org/toc/2041-1723Phospho-MurNAc-pentapeptide translocase (MraY) is a bacterial integral membrane enzyme that is essential for peptidoglycan biosynthesis. Here the authors present the crystal structures of MraY from Aquifex aeolicus bound to caprazamycin, capuramycin and mureidomycin and discuss the implications for antibiotic development.Ellene H. MashalidisBenjamin KaeserYuma TerasawaAkira KatsuyamaDo-Yeon KwonKiyoun LeeJiyong HongSatoshi IchikawaSeok-Yong LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ellene H. Mashalidis Benjamin Kaeser Yuma Terasawa Akira Katsuyama Do-Yeon Kwon Kiyoun Lee Jiyong Hong Satoshi Ichikawa Seok-Yong Lee Chemical logic of MraY inhibition by antibacterial nucleoside natural products
description	Phospho-MurNAc-pentapeptide translocase (MraY) is a bacterial integral membrane enzyme that is essential for peptidoglycan biosynthesis. Here the authors present the crystal structures of MraY from Aquifex aeolicus bound to caprazamycin, capuramycin and mureidomycin and discuss the implications for antibiotic development.
format	article
author	Ellene H. Mashalidis Benjamin Kaeser Yuma Terasawa Akira Katsuyama Do-Yeon Kwon Kiyoun Lee Jiyong Hong Satoshi Ichikawa Seok-Yong Lee
author_facet	Ellene H. Mashalidis Benjamin Kaeser Yuma Terasawa Akira Katsuyama Do-Yeon Kwon Kiyoun Lee Jiyong Hong Satoshi Ichikawa Seok-Yong Lee
author_sort	Ellene H. Mashalidis
title	Chemical logic of MraY inhibition by antibacterial nucleoside natural products
title_short	Chemical logic of MraY inhibition by antibacterial nucleoside natural products
title_full	Chemical logic of MraY inhibition by antibacterial nucleoside natural products
title_fullStr	Chemical logic of MraY inhibition by antibacterial nucleoside natural products
title_full_unstemmed	Chemical logic of MraY inhibition by antibacterial nucleoside natural products
title_sort	chemical logic of mray inhibition by antibacterial nucleoside natural products
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e0558f6d0eab41fcbb345629cf908792
work_keys_str_mv	AT ellenehmashalidis chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT benjaminkaeser chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT yumaterasawa chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT akirakatsuyama chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT doyeonkwon chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT kiyounlee chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT jiyonghong chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT satoshiichikawa chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts AT seokyonglee chemicallogicofmrayinhibitionbyantibacterialnucleosidenaturalproducts
_version_	1718386445464371200

Chemical logic of MraY inhibition by antibacterial nucleoside natural products

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