Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.

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Autores principales:	Xiao L. Chang, Gabriela M. Webb, Helen L. Wu, Justin M. Greene, Shaheed Abdulhaqq, Katherine B. Bateman, Jason S. Reed, Cleiton Pessoa, Whitney C. Weber, Nicholas Maier, Glen M. Chew, Roxanne M. Gilbride, Lina Gao, Rebecca Agnor, Travis Giobbi, Jeffrey Torgerson, Don Siess, Nicole Burnett, Miranda Fischer, Oriene Shiel, Cassandra Moats, Bruce Patterson, Kush Dhody, Scott Kelly, Nader Pourhassan, Diogo M. Magnani, Jeremy Smedley, Benjamin N. Bimber, Nancy L. Haigwood, Scott G. Hansen, Timothy R. Brown, Lishomwa C. Ndhlovu, Jonah B. Sacha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e7
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spelling	oai:doaj.org-article:e057d02dc1bf44278b9075dfe29c62e72021-12-02T14:59:27ZAntibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission10.1038/s41467-021-23697-62041-1723https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23697-6https://doaj.org/toc/2041-1723CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.Xiao L. ChangGabriela M. WebbHelen L. WuJustin M. GreeneShaheed AbdulhaqqKatherine B. BatemanJason S. ReedCleiton PessoaWhitney C. WeberNicholas MaierGlen M. ChewRoxanne M. GilbrideLina GaoRebecca AgnorTravis GiobbiJeffrey TorgersonDon SiessNicole BurnettMiranda FischerOriene ShielCassandra MoatsBruce PattersonKush DhodyScott KellyNader PourhassanDiogo M. MagnaniJeremy SmedleyBenjamin N. BimberNancy L. HaigwoodScott G. HansenTimothy R. BrownLishomwa C. NdhlovuJonah B. SachaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao L. Chang Gabriela M. Webb Helen L. Wu Justin M. Greene Shaheed Abdulhaqq Katherine B. Bateman Jason S. Reed Cleiton Pessoa Whitney C. Weber Nicholas Maier Glen M. Chew Roxanne M. Gilbride Lina Gao Rebecca Agnor Travis Giobbi Jeffrey Torgerson Don Siess Nicole Burnett Miranda Fischer Oriene Shiel Cassandra Moats Bruce Patterson Kush Dhody Scott Kelly Nader Pourhassan Diogo M. Magnani Jeremy Smedley Benjamin N. Bimber Nancy L. Haigwood Scott G. Hansen Timothy R. Brown Lishomwa C. Ndhlovu Jonah B. Sacha Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
description	CCR5 is a co-receptor for many transmitted HIV strains. Here, the authors show that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges of a CCR5-tropic SHIV.
format	article
author	Xiao L. Chang Gabriela M. Webb Helen L. Wu Justin M. Greene Shaheed Abdulhaqq Katherine B. Bateman Jason S. Reed Cleiton Pessoa Whitney C. Weber Nicholas Maier Glen M. Chew Roxanne M. Gilbride Lina Gao Rebecca Agnor Travis Giobbi Jeffrey Torgerson Don Siess Nicole Burnett Miranda Fischer Oriene Shiel Cassandra Moats Bruce Patterson Kush Dhody Scott Kelly Nader Pourhassan Diogo M. Magnani Jeremy Smedley Benjamin N. Bimber Nancy L. Haigwood Scott G. Hansen Timothy R. Brown Lishomwa C. Ndhlovu Jonah B. Sacha
author_facet	Xiao L. Chang Gabriela M. Webb Helen L. Wu Justin M. Greene Shaheed Abdulhaqq Katherine B. Bateman Jason S. Reed Cleiton Pessoa Whitney C. Weber Nicholas Maier Glen M. Chew Roxanne M. Gilbride Lina Gao Rebecca Agnor Travis Giobbi Jeffrey Torgerson Don Siess Nicole Burnett Miranda Fischer Oriene Shiel Cassandra Moats Bruce Patterson Kush Dhody Scott Kelly Nader Pourhassan Diogo M. Magnani Jeremy Smedley Benjamin N. Bimber Nancy L. Haigwood Scott G. Hansen Timothy R. Brown Lishomwa C. Ndhlovu Jonah B. Sacha
author_sort	Xiao L. Chang
title	Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
title_short	Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
title_full	Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
title_fullStr	Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
title_full_unstemmed	Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
title_sort	antibody-based ccr5 blockade protects macaques from mucosal shiv transmission
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e057d02dc1bf44278b9075dfe29c62e7
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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

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