Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies

mRNA translational control by CPEBs is reactivated in cancer. Here, the authors show that the insertion of CPE regulatory sequences in the 3′ UTR of the E1A viral gene induces oncoselectivity, with oncolytic potency in cancer cells but attenuated toxicity in normal tissues.

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Autores principales:	Eneko Villanueva, Pilar Navarro, Maria Rovira-Rigau, Annarita Sibilio, Raúl Méndez, Cristina Fillat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e057e2ac80034205b539e6796fe42a12
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spelling	oai:doaj.org-article:e057e2ac80034205b539e6796fe42a122021-12-02T14:42:06ZTranslational reprogramming in tumour cells can generate oncoselectivity in viral therapies10.1038/ncomms148332041-1723https://doaj.org/article/e057e2ac80034205b539e6796fe42a122017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14833https://doaj.org/toc/2041-1723mRNA translational control by CPEBs is reactivated in cancer. Here, the authors show that the insertion of CPE regulatory sequences in the 3′ UTR of the E1A viral gene induces oncoselectivity, with oncolytic potency in cancer cells but attenuated toxicity in normal tissues.Eneko VillanuevaPilar NavarroMaria Rovira-RigauAnnarita SibilioRaúl MéndezCristina FillatNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eneko Villanueva Pilar Navarro Maria Rovira-Rigau Annarita Sibilio Raúl Méndez Cristina Fillat Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
description	mRNA translational control by CPEBs is reactivated in cancer. Here, the authors show that the insertion of CPE regulatory sequences in the 3′ UTR of the E1A viral gene induces oncoselectivity, with oncolytic potency in cancer cells but attenuated toxicity in normal tissues.
format	article
author	Eneko Villanueva Pilar Navarro Maria Rovira-Rigau Annarita Sibilio Raúl Méndez Cristina Fillat
author_facet	Eneko Villanueva Pilar Navarro Maria Rovira-Rigau Annarita Sibilio Raúl Méndez Cristina Fillat
author_sort	Eneko Villanueva
title	Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
title_short	Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
title_full	Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
title_fullStr	Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
title_full_unstemmed	Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
title_sort	translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e057e2ac80034205b539e6796fe42a12
work_keys_str_mv	AT enekovillanueva translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies AT pilarnavarro translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies AT mariarovirarigau translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies AT annaritasibilio translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies AT raulmendez translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies AT cristinafillat translationalreprogrammingintumourcellscangenerateoncoselectivityinviraltherapies
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Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies

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