Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only...

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Autores principales: Bálint Kintses, Pramod K. Jangir, Gergely Fekete, Mónika Számel, Orsolya Méhi, Réka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Bálint Csörgő, Ádám Györkei, Eszter Ari, Viktória Lázár, István Nagy, Mohan Babu, Csaba Pál, Balázs Papp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/e0586b491c9a457fa943b36f2a4c75e9
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spelling oai:doaj.org-article:e0586b491c9a457fa943b36f2a4c75e92021-12-02T14:39:37ZChemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action10.1038/s41467-019-13618-z2041-1723https://doaj.org/article/e0586b491c9a457fa943b36f2a4c75e92019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13618-zhttps://doaj.org/toc/2041-1723The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action.Bálint KintsesPramod K. JangirGergely FeketeMónika SzámelOrsolya MéhiRéka SpohnLejla DarukaAna MartinsAli HosseinniaAlla GagarinovaSunyoung KimSadhna PhanseBálint CsörgőÁdám GyörkeiEszter AriViktória LázárIstván NagyMohan BabuCsaba PálBalázs PappNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bálint Kintses
Pramod K. Jangir
Gergely Fekete
Mónika Számel
Orsolya Méhi
Réka Spohn
Lejla Daruka
Ana Martins
Ali Hosseinnia
Alla Gagarinova
Sunyoung Kim
Sadhna Phanse
Bálint Csörgő
Ádám Györkei
Eszter Ari
Viktória Lázár
István Nagy
Mohan Babu
Csaba Pál
Balázs Papp
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
description The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action.
format article
author Bálint Kintses
Pramod K. Jangir
Gergely Fekete
Mónika Számel
Orsolya Méhi
Réka Spohn
Lejla Daruka
Ana Martins
Ali Hosseinnia
Alla Gagarinova
Sunyoung Kim
Sadhna Phanse
Bálint Csörgő
Ádám Györkei
Eszter Ari
Viktória Lázár
István Nagy
Mohan Babu
Csaba Pál
Balázs Papp
author_facet Bálint Kintses
Pramod K. Jangir
Gergely Fekete
Mónika Számel
Orsolya Méhi
Réka Spohn
Lejla Daruka
Ana Martins
Ali Hosseinnia
Alla Gagarinova
Sunyoung Kim
Sadhna Phanse
Bálint Csörgő
Ádám Györkei
Eszter Ari
Viktória Lázár
István Nagy
Mohan Babu
Csaba Pál
Balázs Papp
author_sort Bálint Kintses
title Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
title_short Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
title_full Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
title_fullStr Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
title_full_unstemmed Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
title_sort chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/e0586b491c9a457fa943b36f2a4c75e9
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