Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.

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Autores principales:	Sébastien Corre, Nina Tardif, Nicolas Mouchet, Héloïse M. Leclair, Lise Boussemart, Arthur Gautron, Laura Bachelot, Anthony Perrot, Anatoly Soshilov, Aljosja Rogiers, Florian Rambow, Erwan Dumontet, Karin Tarte, Alban Bessede, Gilles J. Guillemin, Jean-Christophe Marine, Michael S. Denison, David Gilot, Marie-Dominique Galibert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e059e48b1f30450aba786bdcd533d146
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spelling	oai:doaj.org-article:e059e48b1f30450aba786bdcd533d1462021-12-02T14:38:48ZSustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma10.1038/s41467-018-06951-22041-1723https://doaj.org/article/e059e48b1f30450aba786bdcd533d1462018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06951-2https://doaj.org/toc/2041-1723Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.Sébastien CorreNina TardifNicolas MouchetHéloïse M. LeclairLise BoussemartArthur GautronLaura BachelotAnthony PerrotAnatoly SoshilovAljosja RogiersFlorian RambowErwan DumontetKarin TarteAlban BessedeGilles J. GuilleminJean-Christophe MarineMichael S. DenisonDavid GilotMarie-Dominique GalibertNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
description	Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice.
format	article
author	Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert
author_facet	Sébastien Corre Nina Tardif Nicolas Mouchet Héloïse M. Leclair Lise Boussemart Arthur Gautron Laura Bachelot Anthony Perrot Anatoly Soshilov Aljosja Rogiers Florian Rambow Erwan Dumontet Karin Tarte Alban Bessede Gilles J. Guillemin Jean-Christophe Marine Michael S. Denison David Gilot Marie-Dominique Galibert
author_sort	Sébastien Corre
title	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_short	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_full	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_fullStr	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_full_unstemmed	Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
title_sort	sustained activation of the aryl hydrocarbon receptor transcription factor promotes resistance to braf-inhibitors in melanoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e059e48b1f30450aba786bdcd533d146
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Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

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