Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.

Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment...

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Autores principales:	Shruti Bansal, Colleen B Jonsson, Shannon L Taylor, Juan Manuel Figueroa, Andrea Vanesa Dugour, Carlos Palacios, Julio César Vega
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e05b1cc5257c495d9083045eb1033e9e
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spelling	oai:doaj.org-article:e05b1cc5257c495d9083045eb1033e9e2021-12-02T20:12:37ZIota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.1932-620310.1371/journal.pone.0259943https://doaj.org/article/e05b1cc5257c495d9083045eb1033e9e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259943https://doaj.org/toc/1932-6203Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment for this disease. Since the nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2, a nasal spray may be an effective option to target SARS-CoV-2 infection. In this study, we tested the antiviral action of three candidate nasal spray formulations against SARS-CoV-2 in vitro. We determined that iota-carrageenan in concentrations as low as 6 μg/mL inhibits SARS-CoV-2 in vitro. The concentrations of iota-carrageenan with activity against SARS-CoV-2 in vitro may be easily achieved through the application of nasal sprays as commonly used in several countries. Recently a double-blind, placebo-controlled study showed that iota-carrageenan in isotonic sodium chloride reduces ca. five times the risk of infection by SARS-CoV-2 in health care personnel. Further, xylitol at a concentration of 50 mg/mL (ca. 329 mM) was found to exert some antiviral action, though this preliminary finding needs further confirmation.Shruti BansalColleen B JonssonShannon L TaylorJuan Manuel FigueroaAndrea Vanesa DugourCarlos PalaciosJulio César VegaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259943 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shruti Bansal Colleen B Jonsson Shannon L Taylor Juan Manuel Figueroa Andrea Vanesa Dugour Carlos Palacios Julio César Vega Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
description	Last year observed a global pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) infection affecting millions of individuals worldwide. There is an urgent unmet need to provide an easily producible and affordable medicine to prevent transmission and provide early treatment for this disease. Since the nasal cavity and the rhinopharynx are the sites of initial replication of SARS-CoV-2, a nasal spray may be an effective option to target SARS-CoV-2 infection. In this study, we tested the antiviral action of three candidate nasal spray formulations against SARS-CoV-2 in vitro. We determined that iota-carrageenan in concentrations as low as 6 μg/mL inhibits SARS-CoV-2 in vitro. The concentrations of iota-carrageenan with activity against SARS-CoV-2 in vitro may be easily achieved through the application of nasal sprays as commonly used in several countries. Recently a double-blind, placebo-controlled study showed that iota-carrageenan in isotonic sodium chloride reduces ca. five times the risk of infection by SARS-CoV-2 in health care personnel. Further, xylitol at a concentration of 50 mg/mL (ca. 329 mM) was found to exert some antiviral action, though this preliminary finding needs further confirmation.
format	article
author	Shruti Bansal Colleen B Jonsson Shannon L Taylor Juan Manuel Figueroa Andrea Vanesa Dugour Carlos Palacios Julio César Vega
author_facet	Shruti Bansal Colleen B Jonsson Shannon L Taylor Juan Manuel Figueroa Andrea Vanesa Dugour Carlos Palacios Julio César Vega
author_sort	Shruti Bansal
title	Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
title_short	Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
title_full	Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
title_fullStr	Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
title_full_unstemmed	Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.
title_sort	iota-carrageenan and xylitol inhibit sars-cov-2 in vero cell culture.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e05b1cc5257c495d9083045eb1033e9e
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Iota-carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture.

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