A simple and fast spectroscopy-based technique for Covid-19 diagnosis

Abstract The coronavirus pandemic, which appeared in Wuhan, China, in December 2019, rapidly spread all over the world in only a few weeks. Faster testing techniques requiring less resources are key in managing the pandemic, either to enable larger scale testing or even just provide developing count...

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Autores principales:	Driss Lahlou Kitane, Salma Loukman, Nabila Marchoudi, Alvaro Fernandez-Galiana, Fatima Zahra El Ansari, Farah Jouali, Jamal Badir, Jean-Luc Gala, Dimitris Bertsimas, Nawfal Azami, Omar Lakbita, Omar Moudam, Rachid Benhida, Jamal Fekkak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e05d1516c27e42da92fd283fc6228f95
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spelling	oai:doaj.org-article:e05d1516c27e42da92fd283fc6228f952021-12-02T18:51:46ZA simple and fast spectroscopy-based technique for Covid-19 diagnosis10.1038/s41598-021-95568-52045-2322https://doaj.org/article/e05d1516c27e42da92fd283fc6228f952021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95568-5https://doaj.org/toc/2045-2322Abstract The coronavirus pandemic, which appeared in Wuhan, China, in December 2019, rapidly spread all over the world in only a few weeks. Faster testing techniques requiring less resources are key in managing the pandemic, either to enable larger scale testing or even just provide developing countries with limited resources, particularly in Africa, means to perform tests to manage the crisis. Here, we report an unprecedented, rapid, reagent-free and easy-to-use screening spectroscopic method for the detection of SARS-CoV-2 on RNA extracts. This method, validated on clinical samples collected from 280 patients with quantitative predictive scores on both positive and negative samples, is based on a multivariate analysis of FTIR spectra of RNA extracts. This technique, in agreement with RT-PCR, achieves 97.8% accuracy, 97% sensitivity and 98.3% specificity while reducing the testing time post RNA extraction from hours to minutes. Furthermore, this technique can be used in several laboratories with limited resources.Driss Lahlou KitaneSalma LoukmanNabila MarchoudiAlvaro Fernandez-GalianaFatima Zahra El AnsariFarah JoualiJamal BadirJean-Luc GalaDimitris BertsimasNawfal AzamiOmar LakbitaOmar MoudamRachid BenhidaJamal FekkakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Driss Lahlou Kitane Salma Loukman Nabila Marchoudi Alvaro Fernandez-Galiana Fatima Zahra El Ansari Farah Jouali Jamal Badir Jean-Luc Gala Dimitris Bertsimas Nawfal Azami Omar Lakbita Omar Moudam Rachid Benhida Jamal Fekkak A simple and fast spectroscopy-based technique for Covid-19 diagnosis
description	Abstract The coronavirus pandemic, which appeared in Wuhan, China, in December 2019, rapidly spread all over the world in only a few weeks. Faster testing techniques requiring less resources are key in managing the pandemic, either to enable larger scale testing or even just provide developing countries with limited resources, particularly in Africa, means to perform tests to manage the crisis. Here, we report an unprecedented, rapid, reagent-free and easy-to-use screening spectroscopic method for the detection of SARS-CoV-2 on RNA extracts. This method, validated on clinical samples collected from 280 patients with quantitative predictive scores on both positive and negative samples, is based on a multivariate analysis of FTIR spectra of RNA extracts. This technique, in agreement with RT-PCR, achieves 97.8% accuracy, 97% sensitivity and 98.3% specificity while reducing the testing time post RNA extraction from hours to minutes. Furthermore, this technique can be used in several laboratories with limited resources.
format	article
author	Driss Lahlou Kitane Salma Loukman Nabila Marchoudi Alvaro Fernandez-Galiana Fatima Zahra El Ansari Farah Jouali Jamal Badir Jean-Luc Gala Dimitris Bertsimas Nawfal Azami Omar Lakbita Omar Moudam Rachid Benhida Jamal Fekkak
author_facet	Driss Lahlou Kitane Salma Loukman Nabila Marchoudi Alvaro Fernandez-Galiana Fatima Zahra El Ansari Farah Jouali Jamal Badir Jean-Luc Gala Dimitris Bertsimas Nawfal Azami Omar Lakbita Omar Moudam Rachid Benhida Jamal Fekkak
author_sort	Driss Lahlou Kitane
title	A simple and fast spectroscopy-based technique for Covid-19 diagnosis
title_short	A simple and fast spectroscopy-based technique for Covid-19 diagnosis
title_full	A simple and fast spectroscopy-based technique for Covid-19 diagnosis
title_fullStr	A simple and fast spectroscopy-based technique for Covid-19 diagnosis
title_full_unstemmed	A simple and fast spectroscopy-based technique for Covid-19 diagnosis
title_sort	simple and fast spectroscopy-based technique for covid-19 diagnosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e05d1516c27e42da92fd283fc6228f95
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A simple and fast spectroscopy-based technique for Covid-19 diagnosis

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