Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis

Abstract Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of cir...

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Autores principales:	Iryna Saranchova, Jeffrey Han, Rysa Zaman, Hitesh Arora, Hui Huang, Franz Fenninger, Kyung Bok Choi, Lonna Munro, Cheryl G. Pfeifer, Ian Welch, Fumio Takei, Wilfred A. Jefferies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e05d74787a9a40e3a597db224e017b20
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spelling	oai:doaj.org-article:e05d74787a9a40e3a597db224e017b202021-12-02T15:08:45ZType 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis10.1038/s41598-018-20608-62045-2322https://doaj.org/article/e05d74787a9a40e3a597db224e017b202018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20608-6https://doaj.org/toc/2045-2322Abstract Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs) and resulting metastasis to distal organs. Our data support the model that IL-33 dependent tumour-infiltrating ILC2s are mobilized from the lungs and other tissues through chemoattraction to enter tumours, and subsequently mediate tumour immune-surveillance by cooperating with dendritic cells to promote adaptive cytolytic T cell responses. We conclude that ILC2s play a fundamental, yet hitherto undescribed role in enhancing anti-cancer immunity and controlling tumour metastasis.Iryna SaranchovaJeffrey HanRysa ZamanHitesh AroraHui HuangFranz FenningerKyung Bok ChoiLonna MunroCheryl G. PfeiferIan WelchFumio TakeiWilfred A. JefferiesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iryna Saranchova Jeffrey Han Rysa Zaman Hitesh Arora Hui Huang Franz Fenninger Kyung Bok Choi Lonna Munro Cheryl G. Pfeifer Ian Welch Fumio Takei Wilfred A. Jefferies Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
description	Abstract Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs) and resulting metastasis to distal organs. Our data support the model that IL-33 dependent tumour-infiltrating ILC2s are mobilized from the lungs and other tissues through chemoattraction to enter tumours, and subsequently mediate tumour immune-surveillance by cooperating with dendritic cells to promote adaptive cytolytic T cell responses. We conclude that ILC2s play a fundamental, yet hitherto undescribed role in enhancing anti-cancer immunity and controlling tumour metastasis.
format	article
author	Iryna Saranchova Jeffrey Han Rysa Zaman Hitesh Arora Hui Huang Franz Fenninger Kyung Bok Choi Lonna Munro Cheryl G. Pfeifer Ian Welch Fumio Takei Wilfred A. Jefferies
author_facet	Iryna Saranchova Jeffrey Han Rysa Zaman Hitesh Arora Hui Huang Franz Fenninger Kyung Bok Choi Lonna Munro Cheryl G. Pfeifer Ian Welch Fumio Takei Wilfred A. Jefferies
author_sort	Iryna Saranchova
title	Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
title_short	Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
title_full	Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
title_fullStr	Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
title_full_unstemmed	Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis
title_sort	type 2 innate lymphocytes actuate immunity against tumours and limit cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e05d74787a9a40e3a597db224e017b20
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Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis

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