O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

SIRT1 is a stress sensor whose deacetylase activity is increased during cellular stress, but the molecular mechanism is unclear. Here, the authors show that O-GlcNAcylation of SIRT1 is elevated upon different stress stimuli and increases SIRT1 deacetylase activity, protecting cells from stress-induc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cuifang Han, Yuchao Gu, Hui Shan, Wenyi Mi, Jiahui Sun, Minghui Shi, Xinling Zhang, Xinzhi Lu, Feng Han, Qianhong Gong, Wengong Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e0611664b7764e24b6f08b4487935b48
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e0611664b7764e24b6f08b4487935b48
record_format	dspace
spelling	oai:doaj.org-article:e0611664b7764e24b6f08b4487935b482021-12-02T17:06:22ZO-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress10.1038/s41467-017-01654-62041-1723https://doaj.org/article/e0611664b7764e24b6f08b4487935b482017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01654-6https://doaj.org/toc/2041-1723SIRT1 is a stress sensor whose deacetylase activity is increased during cellular stress, but the molecular mechanism is unclear. Here, the authors show that O-GlcNAcylation of SIRT1 is elevated upon different stress stimuli and increases SIRT1 deacetylase activity, protecting cells from stress-induced apoptosis.Cuifang HanYuchao GuHui ShanWenyi MiJiahui SunMinghui ShiXinling ZhangXinzhi LuFeng HanQianhong GongWengong YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cuifang Han Yuchao Gu Hui Shan Wenyi Mi Jiahui Sun Minghui Shi Xinling Zhang Xinzhi Lu Feng Han Qianhong Gong Wengong Yu O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
description	SIRT1 is a stress sensor whose deacetylase activity is increased during cellular stress, but the molecular mechanism is unclear. Here, the authors show that O-GlcNAcylation of SIRT1 is elevated upon different stress stimuli and increases SIRT1 deacetylase activity, protecting cells from stress-induced apoptosis.
format	article
author	Cuifang Han Yuchao Gu Hui Shan Wenyi Mi Jiahui Sun Minghui Shi Xinling Zhang Xinzhi Lu Feng Han Qianhong Gong Wengong Yu
author_facet	Cuifang Han Yuchao Gu Hui Shan Wenyi Mi Jiahui Sun Minghui Shi Xinling Zhang Xinzhi Lu Feng Han Qianhong Gong Wengong Yu
author_sort	Cuifang Han
title	O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
title_short	O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
title_full	O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
title_fullStr	O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
title_full_unstemmed	O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress
title_sort	o-glcnacylation of sirt1 enhances its deacetylase activity and promotes cytoprotection under stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e0611664b7764e24b6f08b4487935b48
work_keys_str_mv	AT cuifanghan oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT yuchaogu oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT huishan oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT wenyimi oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT jiahuisun oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT minghuishi oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT xinlingzhang oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT xinzhilu oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT fenghan oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT qianhonggong oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress AT wengongyu oglcnacylationofsirt1enhancesitsdeacetylaseactivityandpromotescytoprotectionunderstress
_version_	1718381645353975808

O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress

Ejemplares similares