<i>Aspergillus fumigatus</i> Fumagillin Contributes to Host Cell Damage

<i>Aspergillus fumigatus</i> Fumagillin Contributes to Host Cell Damage

The activity of fumagillin, a mycotoxin produced by <i>Aspergillus fumigatus</i>, has not been studied in depth. In this study, we used a commercial fumagillin on cultures of two cell types (A549 pneumocytes and RAW 264.7 macrophages). This toxin joins its target, MetAP2 protein, inside...

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Bibliographic Details
Main Authors: Xabier Guruceaga, Uxue Perez-Cuesta, Aize Pellon, Saioa Cendon-Sanchez, Eduardo Pelegri-Martinez, Oskar Gonzalez, Fernando Luis Hernando, Emilio Mayayo, Juan Anguita, Rosa M. Alonso, Nancy P. Keller, Andoni Ramirez-Garcia, Aitor Rementeria
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
fumagillin
<i>Aspergillus fumigatus</i>
virulence factor
pathogenesis
RAW 264.7
A549
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/e06448526b3e4decb5db64303b6d2e08
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