Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.

<h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesi...

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Autores principales: Yi-Hsuan Huang, Zhi-Fu Wu, Meei-Shyuan Lee, Yu-Sheng Lou, Ke-Li Wu, Kuang-I Cheng, Hou-Chuan Lai
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spelling oai:doaj.org-article:e064c794244d45ef9a1899fb0fac30022021-12-02T20:18:39ZPropofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.1932-620310.1371/journal.pone.0255627https://doaj.org/article/e064c794244d45ef9a1899fb0fac30022021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255627https://doaj.org/toc/1932-6203<h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesia and patient outcomes following elective glioblastoma surgery.<h4>Methods</h4>This was a retrospective cohort study of patients who underwent elective glioblastoma surgery between January 2008 and December 2018. Patients were grouped according to the anesthesia they received, desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival curves were presented from the date of surgery to death. Univariable and multivariable Cox regression models were used to compare hazard ratios for death after propensity matching.<h4>Results</h4>A total of 50 patients (45 deaths, 90.0%) under desflurane anesthesia and 53 patients (38 deaths, 72.0%) under propofol anesthesia were included. Thirty-eight patients remained in each group after propensity matching. Propofol anesthesia was associated with improved survival (hazard ratio, 0.51; 95% confidence interval, 0.30-0.85; P = 0.011) in a matched analysis. Furthermore, patients under propofol anesthesia exhibited less postoperative recurrence than those under desflurane anesthesia (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98; P = 0.040) in a matched analysis.<h4>Conclusions</h4>In this limited sample size, we observed that propofol anesthesia was associated with improved survival and less postoperative recurrence in glioblastoma surgery than desflurane anesthesia. Further investigations are needed to examine the influence of propofol anesthesia on patient outcomes following glioblastoma surgery.Yi-Hsuan HuangZhi-Fu WuMeei-Shyuan LeeYu-Sheng LouKe-Li WuKuang-I ChengHou-Chuan LaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255627 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yi-Hsuan Huang
Zhi-Fu Wu
Meei-Shyuan Lee
Yu-Sheng Lou
Ke-Li Wu
Kuang-I Cheng
Hou-Chuan Lai
Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
description <h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesia and patient outcomes following elective glioblastoma surgery.<h4>Methods</h4>This was a retrospective cohort study of patients who underwent elective glioblastoma surgery between January 2008 and December 2018. Patients were grouped according to the anesthesia they received, desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival curves were presented from the date of surgery to death. Univariable and multivariable Cox regression models were used to compare hazard ratios for death after propensity matching.<h4>Results</h4>A total of 50 patients (45 deaths, 90.0%) under desflurane anesthesia and 53 patients (38 deaths, 72.0%) under propofol anesthesia were included. Thirty-eight patients remained in each group after propensity matching. Propofol anesthesia was associated with improved survival (hazard ratio, 0.51; 95% confidence interval, 0.30-0.85; P = 0.011) in a matched analysis. Furthermore, patients under propofol anesthesia exhibited less postoperative recurrence than those under desflurane anesthesia (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98; P = 0.040) in a matched analysis.<h4>Conclusions</h4>In this limited sample size, we observed that propofol anesthesia was associated with improved survival and less postoperative recurrence in glioblastoma surgery than desflurane anesthesia. Further investigations are needed to examine the influence of propofol anesthesia on patient outcomes following glioblastoma surgery.
format article
author Yi-Hsuan Huang
Zhi-Fu Wu
Meei-Shyuan Lee
Yu-Sheng Lou
Ke-Li Wu
Kuang-I Cheng
Hou-Chuan Lai
author_facet Yi-Hsuan Huang
Zhi-Fu Wu
Meei-Shyuan Lee
Yu-Sheng Lou
Ke-Li Wu
Kuang-I Cheng
Hou-Chuan Lai
author_sort Yi-Hsuan Huang
title Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_short Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_full Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_fullStr Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_full_unstemmed Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_sort propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/e064c794244d45ef9a1899fb0fac3002
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