Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.

<h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi-Hsuan Huang, Zhi-Fu Wu, Meei-Shyuan Lee, Yu-Sheng Lou, Ke-Li Wu, Kuang-I Cheng, Hou-Chuan Lai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e064c794244d45ef9a1899fb0fac3002
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e064c794244d45ef9a1899fb0fac3002
record_format	dspace
spelling	oai:doaj.org-article:e064c794244d45ef9a1899fb0fac30022021-12-02T20:18:39ZPropofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.1932-620310.1371/journal.pone.0255627https://doaj.org/article/e064c794244d45ef9a1899fb0fac30022021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255627https://doaj.org/toc/1932-6203<h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesia and patient outcomes following elective glioblastoma surgery.<h4>Methods</h4>This was a retrospective cohort study of patients who underwent elective glioblastoma surgery between January 2008 and December 2018. Patients were grouped according to the anesthesia they received, desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival curves were presented from the date of surgery to death. Univariable and multivariable Cox regression models were used to compare hazard ratios for death after propensity matching.<h4>Results</h4>A total of 50 patients (45 deaths, 90.0%) under desflurane anesthesia and 53 patients (38 deaths, 72.0%) under propofol anesthesia were included. Thirty-eight patients remained in each group after propensity matching. Propofol anesthesia was associated with improved survival (hazard ratio, 0.51; 95% confidence interval, 0.30-0.85; P = 0.011) in a matched analysis. Furthermore, patients under propofol anesthesia exhibited less postoperative recurrence than those under desflurane anesthesia (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98; P = 0.040) in a matched analysis.<h4>Conclusions</h4>In this limited sample size, we observed that propofol anesthesia was associated with improved survival and less postoperative recurrence in glioblastoma surgery than desflurane anesthesia. Further investigations are needed to examine the influence of propofol anesthesia on patient outcomes following glioblastoma surgery.Yi-Hsuan HuangZhi-Fu WuMeei-Shyuan LeeYu-Sheng LouKe-Li WuKuang-I ChengHou-Chuan LaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255627 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Hsuan Huang Zhi-Fu Wu Meei-Shyuan Lee Yu-Sheng Lou Ke-Li Wu Kuang-I Cheng Hou-Chuan Lai Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
description	<h4>Background</h4>Previous research has shown that anesthetic techniques can influence patient outcomes following cancer surgery. However, the effects of anesthesia in patients undergoing glioblastoma surgery are still not known. We studied the relationship between the type of anesthesia and patient outcomes following elective glioblastoma surgery.<h4>Methods</h4>This was a retrospective cohort study of patients who underwent elective glioblastoma surgery between January 2008 and December 2018. Patients were grouped according to the anesthesia they received, desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival curves were presented from the date of surgery to death. Univariable and multivariable Cox regression models were used to compare hazard ratios for death after propensity matching.<h4>Results</h4>A total of 50 patients (45 deaths, 90.0%) under desflurane anesthesia and 53 patients (38 deaths, 72.0%) under propofol anesthesia were included. Thirty-eight patients remained in each group after propensity matching. Propofol anesthesia was associated with improved survival (hazard ratio, 0.51; 95% confidence interval, 0.30-0.85; P = 0.011) in a matched analysis. Furthermore, patients under propofol anesthesia exhibited less postoperative recurrence than those under desflurane anesthesia (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98; P = 0.040) in a matched analysis.<h4>Conclusions</h4>In this limited sample size, we observed that propofol anesthesia was associated with improved survival and less postoperative recurrence in glioblastoma surgery than desflurane anesthesia. Further investigations are needed to examine the influence of propofol anesthesia on patient outcomes following glioblastoma surgery.
format	article
author	Yi-Hsuan Huang Zhi-Fu Wu Meei-Shyuan Lee Yu-Sheng Lou Ke-Li Wu Kuang-I Cheng Hou-Chuan Lai
author_facet	Yi-Hsuan Huang Zhi-Fu Wu Meei-Shyuan Lee Yu-Sheng Lou Ke-Li Wu Kuang-I Cheng Hou-Chuan Lai
author_sort	Yi-Hsuan Huang
title	Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_short	Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_full	Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_fullStr	Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_full_unstemmed	Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
title_sort	propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e064c794244d45ef9a1899fb0fac3002
work_keys_str_mv	AT yihsuanhuang propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT zhifuwu propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT meeishyuanlee propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT yushenglou propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT keliwu propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT kuangicheng propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery AT houchuanlai propofolbasedtotalintravenousanesthesiaisassociatedwithbettersurvivalthandesfluraneanesthesiainglioblastomasurgery
_version_	1718374257037148160

Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in glioblastoma surgery.

Ejemplares similares