Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium

Rare small cell neuroendocrine carcinoma (SCNEC) cases showed alpha fetoprotein (AFP) expression in the endometrium. In this study, we reported a case of uterine SCNEC expressing AFP. In addition, a literature review was performed to investigate the potential mechanism and the clinicopathological fe...

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Autores principales:	Hou Weiwei, Zhou Bin, Hou Gang, Pang Yu, Sang Jing, Li Ning
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	alpha-fetoprotein small cell neuroendocrine carcinoma immunohistochemistry endometrium vaginal bleeding Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e065281b0c4c469ab47198611b22ad44
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spelling	oai:doaj.org-article:e065281b0c4c469ab47198611b22ad442021-12-05T14:10:42ZSmall cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium2391-541210.1515/biol-2021-0122https://doaj.org/article/e065281b0c4c469ab47198611b22ad442021-11-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0122https://doaj.org/toc/2391-5412Rare small cell neuroendocrine carcinoma (SCNEC) cases showed alpha fetoprotein (AFP) expression in the endometrium. In this study, we reported a case of uterine SCNEC expressing AFP. In addition, a literature review was performed to investigate the potential mechanism and the clinicopathological features of SCNEC to provide clinical guidance. A 65-year-old female was referred to our hospital due to vaginal bleeding for 1 month in November 2020. The clinical features were summarized. After total hysterectomy and removal of bilateral appendages, the histological examination and immunohistochemistry examination were performed. Histological findings showed that the cancer cells were arranged in a nest-like pattern distributed in a lamellar manner. The smooth muscles of the uterus were invaded by cancer cells. Cancer cells were relatively consistent in size. Small glandular duct-like and rosettes-like structures were distinguished, together with necrotic tissues. The deep staining showed that the amount of cytoplasm was lower in the nucleus. Partial cancer cells had small nucleolus with an irregular profile. There were some mitotic figures. Immunohistochemistry examination indicated that there was a diffuse expression of CK, Syn, CgA, CD56, CK8/18, P16, AFP, HepPar-1, Glypican-3, and Ki67 (90%). In this case, we reported a SCNEC patient expressing AFP, Glypican-3, and HepPar-1.Hou WeiweiZhou BinHou GangPang YuSang JingLi NingDe Gruyterarticlealpha-fetoproteinsmall cell neuroendocrine carcinomaimmunohistochemistryendometriumvaginal bleedingBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 1219-1224 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alpha-fetoprotein small cell neuroendocrine carcinoma immunohistochemistry endometrium vaginal bleeding Biology (General) QH301-705.5
spellingShingle	alpha-fetoprotein small cell neuroendocrine carcinoma immunohistochemistry endometrium vaginal bleeding Biology (General) QH301-705.5 Hou Weiwei Zhou Bin Hou Gang Pang Yu Sang Jing Li Ning Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
description	Rare small cell neuroendocrine carcinoma (SCNEC) cases showed alpha fetoprotein (AFP) expression in the endometrium. In this study, we reported a case of uterine SCNEC expressing AFP. In addition, a literature review was performed to investigate the potential mechanism and the clinicopathological features of SCNEC to provide clinical guidance. A 65-year-old female was referred to our hospital due to vaginal bleeding for 1 month in November 2020. The clinical features were summarized. After total hysterectomy and removal of bilateral appendages, the histological examination and immunohistochemistry examination were performed. Histological findings showed that the cancer cells were arranged in a nest-like pattern distributed in a lamellar manner. The smooth muscles of the uterus were invaded by cancer cells. Cancer cells were relatively consistent in size. Small glandular duct-like and rosettes-like structures were distinguished, together with necrotic tissues. The deep staining showed that the amount of cytoplasm was lower in the nucleus. Partial cancer cells had small nucleolus with an irregular profile. There were some mitotic figures. Immunohistochemistry examination indicated that there was a diffuse expression of CK, Syn, CgA, CD56, CK8/18, P16, AFP, HepPar-1, Glypican-3, and Ki67 (90%). In this case, we reported a SCNEC patient expressing AFP, Glypican-3, and HepPar-1.
format	article
author	Hou Weiwei Zhou Bin Hou Gang Pang Yu Sang Jing Li Ning
author_facet	Hou Weiwei Zhou Bin Hou Gang Pang Yu Sang Jing Li Ning
author_sort	Hou Weiwei
title	Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
title_short	Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
title_full	Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
title_fullStr	Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
title_full_unstemmed	Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
title_sort	small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/e065281b0c4c469ab47198611b22ad44
work_keys_str_mv	AT houweiwei smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium AT zhoubin smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium AT hougang smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium AT pangyu smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium AT sangjing smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium AT lining smallcellneuroendocrinecarcinomaexpressingalphafetoproteinintheendometrium
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Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium

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