Alveologenesis: What Governs Secondary Septa Formation

The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and...

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Autores principales:	Alexandra L. Rippa, Elena V. Alpeeva, Andrey V. Vasiliev, Ekaterina A. Vorotelyak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	alveologenesis secondary septa alveolar interstitial resident fibroblasts myofibroblasts lipofibroblasts retinoic acid signaling Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e0653b0fa1e746e9a159fb7a2955314b
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spelling	oai:doaj.org-article:e0653b0fa1e746e9a159fb7a2955314b2021-11-25T17:53:27ZAlveologenesis: What Governs Secondary Septa Formation10.3390/ijms2222121071422-00671661-6596https://doaj.org/article/e0653b0fa1e746e9a159fb7a2955314b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12107https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and neo-alveolarization is required in an efficient search for therapeutic approaches. In this review, we describe the formation of the gas exchange units of the lung as a multifactorial process, which includes changes in the actomyosin cytoskeleton of alveocytes and myofibroblasts, elastogenesis, retinoic acid signaling, and the contribution of alveolar mesenchymal cells in secondary septation. Knowledge of the mechanistic context of alveologenesis remains incomplete. The characterization of the mechanisms that govern the emergence and depletion of αSMA will allow for an understanding of how the niche of fibroblasts is changing. Taking into account the intense studies that have been performed on the pool of lung mesenchymal cells, we present data on the typing of interstitial fibroblasts and their role in the formation and maintenance of alveoli. On the whole, when identifying cell subpopulations in lung mesenchyme, one has to consider the developmental context, the changing cellular functions, and the lability of gene signatures.Alexandra L. RippaElena V. AlpeevaAndrey V. VasilievEkaterina A. VorotelyakMDPI AGarticlealveologenesissecondary septaalveolar interstitial resident fibroblastsmyofibroblastslipofibroblastsretinoic acid signalingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12107, p 12107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alveologenesis secondary septa alveolar interstitial resident fibroblasts myofibroblasts lipofibroblasts retinoic acid signaling Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	alveologenesis secondary septa alveolar interstitial resident fibroblasts myofibroblasts lipofibroblasts retinoic acid signaling Biology (General) QH301-705.5 Chemistry QD1-999 Alexandra L. Rippa Elena V. Alpeeva Andrey V. Vasiliev Ekaterina A. Vorotelyak Alveologenesis: What Governs Secondary Septa Formation
description	The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and neo-alveolarization is required in an efficient search for therapeutic approaches. In this review, we describe the formation of the gas exchange units of the lung as a multifactorial process, which includes changes in the actomyosin cytoskeleton of alveocytes and myofibroblasts, elastogenesis, retinoic acid signaling, and the contribution of alveolar mesenchymal cells in secondary septation. Knowledge of the mechanistic context of alveologenesis remains incomplete. The characterization of the mechanisms that govern the emergence and depletion of αSMA will allow for an understanding of how the niche of fibroblasts is changing. Taking into account the intense studies that have been performed on the pool of lung mesenchymal cells, we present data on the typing of interstitial fibroblasts and their role in the formation and maintenance of alveoli. On the whole, when identifying cell subpopulations in lung mesenchyme, one has to consider the developmental context, the changing cellular functions, and the lability of gene signatures.
format	article
author	Alexandra L. Rippa Elena V. Alpeeva Andrey V. Vasiliev Ekaterina A. Vorotelyak
author_facet	Alexandra L. Rippa Elena V. Alpeeva Andrey V. Vasiliev Ekaterina A. Vorotelyak
author_sort	Alexandra L. Rippa
title	Alveologenesis: What Governs Secondary Septa Formation
title_short	Alveologenesis: What Governs Secondary Septa Formation
title_full	Alveologenesis: What Governs Secondary Septa Formation
title_fullStr	Alveologenesis: What Governs Secondary Septa Formation
title_full_unstemmed	Alveologenesis: What Governs Secondary Septa Formation
title_sort	alveologenesis: what governs secondary septa formation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e0653b0fa1e746e9a159fb7a2955314b
work_keys_str_mv	AT alexandralrippa alveologenesiswhatgovernssecondaryseptaformation AT elenavalpeeva alveologenesiswhatgovernssecondaryseptaformation AT andreyvvasiliev alveologenesiswhatgovernssecondaryseptaformation AT ekaterinaavorotelyak alveologenesiswhatgovernssecondaryseptaformation
_version_	1718411893777891328

Alveologenesis: What Governs Secondary Septa Formation

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