A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent...

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Autor principal:	Kenneth R. Olson
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypoxia hypoxic vasoconstriction hypoxic vasodilation chemoreceptor carotid body chromaffin cell Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e06569e4660046468e84db712d6e9abd
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spelling	oai:doaj.org-article:e06569e4660046468e84db712d6e9abd2021-11-25T16:25:20ZA Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism10.3390/antiox101116502076-3921https://doaj.org/article/e06569e4660046468e84db712d6e9abd2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1650https://doaj.org/toc/2076-3921The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H<sub>2</sub>S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O<sub>2</sub> sensing mechanism. This hypothesis is based on observations that H<sub>2</sub>S and RSS metabolism is inversely correlated with O<sub>2</sub> tension, exogenous H<sub>2</sub>S elicits physiological responses identical to those produced by hypoxia, factors that affect H<sub>2</sub>S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O<sub>2</sub>. H<sub>2</sub>S-mediated O<sub>2</sub> sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O<sub>2</sub> sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.Kenneth R. OlsonMDPI AGarticlehypoxiahypoxic vasoconstrictionhypoxic vasodilationchemoreceptorcarotid bodychromaffin cellTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1650, p 1650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxia hypoxic vasoconstriction hypoxic vasodilation chemoreceptor carotid body chromaffin cell Therapeutics. Pharmacology RM1-950
spellingShingle	hypoxia hypoxic vasoconstriction hypoxic vasodilation chemoreceptor carotid body chromaffin cell Therapeutics. Pharmacology RM1-950 Kenneth R. Olson A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
description	The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H<sub>2</sub>S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O<sub>2</sub> sensing mechanism. This hypothesis is based on observations that H<sub>2</sub>S and RSS metabolism is inversely correlated with O<sub>2</sub> tension, exogenous H<sub>2</sub>S elicits physiological responses identical to those produced by hypoxia, factors that affect H<sub>2</sub>S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O<sub>2</sub>. H<sub>2</sub>S-mediated O<sub>2</sub> sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O<sub>2</sub> sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.
format	article
author	Kenneth R. Olson
author_facet	Kenneth R. Olson
author_sort	Kenneth R. Olson
title	A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
title_short	A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
title_full	A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
title_fullStr	A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
title_full_unstemmed	A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism
title_sort	case for hydrogen sulfide metabolism as an oxygen sensing mechanism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e06569e4660046468e84db712d6e9abd
work_keys_str_mv	AT kennethrolson acaseforhydrogensulfidemetabolismasanoxygensensingmechanism AT kennethrolson caseforhydrogensulfidemetabolismasanoxygensensingmechanism
_version_	1718413231932833792

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

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