Distinct arsenic metabolites following seaweed consumption in humans

Abstract Seaweeds contain arsenic primarily in the form of arsenosugars, which can be metabolized to a wide range of arsenic compounds. To characterize human exposure to arsenic from seaweed consumption, we determined concentrations of arsenic species in locally available seaweeds, and assessed urin...

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Autores principales:	Vivien F. Taylor, Zhigang Li, Vicki Sayarath, Thomas J. Palys, Kevin R. Morse, Rachel A. Scholz-Bright, Margaret R. Karagas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e06623a5b3dd49f3a233798baa572284
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spelling	oai:doaj.org-article:e06623a5b3dd49f3a233798baa5722842021-12-02T12:30:36ZDistinct arsenic metabolites following seaweed consumption in humans10.1038/s41598-017-03883-72045-2322https://doaj.org/article/e06623a5b3dd49f3a233798baa5722842017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03883-7https://doaj.org/toc/2045-2322Abstract Seaweeds contain arsenic primarily in the form of arsenosugars, which can be metabolized to a wide range of arsenic compounds. To characterize human exposure to arsenic from seaweed consumption, we determined concentrations of arsenic species in locally available seaweeds, and assessed urinary arsenic compounds in an experimental feeding study. A total of 11 volunteers consumed 10 g per day of three types of seaweeds (nori, kombu, and wakame) for three days each, while abstaining from rice and seafood following a three-day washout period. Urinary arsenosugars and their metabolites (including dimethyl arsenate (DMA), thio-dimethylarsinoylethanol (thio-DMAE), thio-dimethylarsinoylacetate (thio-DMAA), and thio-DMA) were measured in spot urine samples prior to seaweed consumption, and in 24-hour urine samples while consuming seaweed. Commercial products made from whole seaweed had substantial concentrations of arsenic (12–84 µg/g), dominated by arsenosugars. Intact arsenosugars along with DMA, thio-DMAA, thio-DMAE all increased in urine after ingesting each type of seaweed, and varied between seaweed types and between individuals. Only trace levels of the known toxic metabolite, thio-DMA, were observed, across individuals. Thio-DMAE and thio-DMAA are unique products of arsenosugar breakdown, thus assessment of these compounds may help to identify dietary intake of arsenic from seaweed from other exposure pathways.Vivien F. TaylorZhigang LiVicki SayarathThomas J. PalysKevin R. MorseRachel A. Scholz-BrightMargaret R. KaragasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vivien F. Taylor Zhigang Li Vicki Sayarath Thomas J. Palys Kevin R. Morse Rachel A. Scholz-Bright Margaret R. Karagas Distinct arsenic metabolites following seaweed consumption in humans
description	Abstract Seaweeds contain arsenic primarily in the form of arsenosugars, which can be metabolized to a wide range of arsenic compounds. To characterize human exposure to arsenic from seaweed consumption, we determined concentrations of arsenic species in locally available seaweeds, and assessed urinary arsenic compounds in an experimental feeding study. A total of 11 volunteers consumed 10 g per day of three types of seaweeds (nori, kombu, and wakame) for three days each, while abstaining from rice and seafood following a three-day washout period. Urinary arsenosugars and their metabolites (including dimethyl arsenate (DMA), thio-dimethylarsinoylethanol (thio-DMAE), thio-dimethylarsinoylacetate (thio-DMAA), and thio-DMA) were measured in spot urine samples prior to seaweed consumption, and in 24-hour urine samples while consuming seaweed. Commercial products made from whole seaweed had substantial concentrations of arsenic (12–84 µg/g), dominated by arsenosugars. Intact arsenosugars along with DMA, thio-DMAA, thio-DMAE all increased in urine after ingesting each type of seaweed, and varied between seaweed types and between individuals. Only trace levels of the known toxic metabolite, thio-DMA, were observed, across individuals. Thio-DMAE and thio-DMAA are unique products of arsenosugar breakdown, thus assessment of these compounds may help to identify dietary intake of arsenic from seaweed from other exposure pathways.
format	article
author	Vivien F. Taylor Zhigang Li Vicki Sayarath Thomas J. Palys Kevin R. Morse Rachel A. Scholz-Bright Margaret R. Karagas
author_facet	Vivien F. Taylor Zhigang Li Vicki Sayarath Thomas J. Palys Kevin R. Morse Rachel A. Scholz-Bright Margaret R. Karagas
author_sort	Vivien F. Taylor
title	Distinct arsenic metabolites following seaweed consumption in humans
title_short	Distinct arsenic metabolites following seaweed consumption in humans
title_full	Distinct arsenic metabolites following seaweed consumption in humans
title_fullStr	Distinct arsenic metabolites following seaweed consumption in humans
title_full_unstemmed	Distinct arsenic metabolites following seaweed consumption in humans
title_sort	distinct arsenic metabolites following seaweed consumption in humans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e06623a5b3dd49f3a233798baa572284
work_keys_str_mv	AT vivienftaylor distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT zhigangli distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT vickisayarath distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT thomasjpalys distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT kevinrmorse distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT rachelascholzbright distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans AT margaretrkaragas distinctarsenicmetabolitesfollowingseaweedconsumptioninhumans
_version_	1718394367590268928

Distinct arsenic metabolites following seaweed consumption in humans

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