Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to aggresomes through the interactions of DCTN1 with dyne...

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Autores principales:	Joori Park, Yeonkyoung Park, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, Yoon Ki Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e069530b25f54b8f8ecf80f03d95dc22
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spelling	oai:doaj.org-article:e069530b25f54b8f8ecf80f03d95dc222021-12-02T17:06:05ZMisfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex10.1038/ncomms157302041-1723https://doaj.org/article/e069530b25f54b8f8ecf80f03d95dc222017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15730https://doaj.org/toc/2041-1723Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to aggresomes through the interactions of DCTN1 with dynein motors.Joori ParkYeonkyoung ParkIncheol RyuMi-Hyun ChoiHyo Jin LeeNara OhKyutae KimKyoung Mi KimJunho ChoeCheolju LeeJa-Hyun BaikYoon Ki KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joori Park Yeonkyoung Park Incheol Ryu Mi-Hyun Choi Hyo Jin Lee Nara Oh Kyutae Kim Kyoung Mi Kim Junho Choe Cheolju Lee Ja-Hyun Baik Yoon Ki Kim Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
description	Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to aggresomes through the interactions of DCTN1 with dynein motors.
format	article
author	Joori Park Yeonkyoung Park Incheol Ryu Mi-Hyun Choi Hyo Jin Lee Nara Oh Kyutae Kim Kyoung Mi Kim Junho Choe Cheolju Lee Ja-Hyun Baik Yoon Ki Kim
author_facet	Joori Park Yeonkyoung Park Incheol Ryu Mi-Hyun Choi Hyo Jin Lee Nara Oh Kyutae Kim Kyoung Mi Kim Junho Choe Cheolju Lee Ja-Hyun Baik Yoon Ki Kim
author_sort	Joori Park
title	Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
title_short	Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
title_full	Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
title_fullStr	Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
title_full_unstemmed	Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex
title_sort	misfolded polypeptides are selectively recognized and transported toward aggresomes by a ced complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e069530b25f54b8f8ecf80f03d95dc22
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Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

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