Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system

Abstract Chronic obstructive pulmonary disease (COPD) produces skeletal muscle atrophy and weakness, leading to impairments of exercise performance. The mechanical work needed for movement execution is also provided by the passive tension developed by musculoarticular connective tissue. To verify wh...

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Autores principales:	Maria Stella Valle, Antonino Casabona, Eugenia Di Fazio, Claudia Crimi, Cristina Russo, Lucia Malaguarnera, Nunzio Crimi, Matteo Cioni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e069f6202571426090b02b2dcd35e36c
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spelling	oai:doaj.org-article:e069f6202571426090b02b2dcd35e36c2021-12-02T17:41:13ZImpact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system10.1038/s41598-021-97621-92045-2322https://doaj.org/article/e069f6202571426090b02b2dcd35e36c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97621-9https://doaj.org/toc/2045-2322Abstract Chronic obstructive pulmonary disease (COPD) produces skeletal muscle atrophy and weakness, leading to impairments of exercise performance. The mechanical work needed for movement execution is also provided by the passive tension developed by musculoarticular connective tissue. To verify whether COPD affects this component, the passive viscoelastic properties of the knee joint were evaluated in 11 patients with COPD and in 11 healthy individuals. The levels of stiffness and viscosity were assessed by means of the pendulum test, consisting in a series of passive leg oscillations. In addition, to explore the contribution of passive tension in the mechanical output of a simple motor task, voluntary leg flexion–extension movements were performed. Patients with COPD showed a statistically significant reduction in stiffness and viscosity compared to controls. Voluntary execution of flexion–extension movements revealed that the electromyographic activity of the Rectus Femoris and Biceps Femoris was lower in patients than in controls, and the low viscoelastic tension in the patients conditioned the performance of active movements. These results provide novel insights on the mechanism responsible for the movement impairments associated with COPD.Maria Stella ValleAntonino CasabonaEugenia Di FazioClaudia CrimiCristina RussoLucia MalaguarneraNunzio CrimiMatteo CioniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Stella Valle Antonino Casabona Eugenia Di Fazio Claudia Crimi Cristina Russo Lucia Malaguarnera Nunzio Crimi Matteo Cioni Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
description	Abstract Chronic obstructive pulmonary disease (COPD) produces skeletal muscle atrophy and weakness, leading to impairments of exercise performance. The mechanical work needed for movement execution is also provided by the passive tension developed by musculoarticular connective tissue. To verify whether COPD affects this component, the passive viscoelastic properties of the knee joint were evaluated in 11 patients with COPD and in 11 healthy individuals. The levels of stiffness and viscosity were assessed by means of the pendulum test, consisting in a series of passive leg oscillations. In addition, to explore the contribution of passive tension in the mechanical output of a simple motor task, voluntary leg flexion–extension movements were performed. Patients with COPD showed a statistically significant reduction in stiffness and viscosity compared to controls. Voluntary execution of flexion–extension movements revealed that the electromyographic activity of the Rectus Femoris and Biceps Femoris was lower in patients than in controls, and the low viscoelastic tension in the patients conditioned the performance of active movements. These results provide novel insights on the mechanism responsible for the movement impairments associated with COPD.
format	article
author	Maria Stella Valle Antonino Casabona Eugenia Di Fazio Claudia Crimi Cristina Russo Lucia Malaguarnera Nunzio Crimi Matteo Cioni
author_facet	Maria Stella Valle Antonino Casabona Eugenia Di Fazio Claudia Crimi Cristina Russo Lucia Malaguarnera Nunzio Crimi Matteo Cioni
author_sort	Maria Stella Valle
title	Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
title_short	Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
title_full	Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
title_fullStr	Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
title_full_unstemmed	Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
title_sort	impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e069f6202571426090b02b2dcd35e36c
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Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system

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