ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled

ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP hydrolysis. Here, the authors show that the bacterial transporter MsbA requires additional energy from the transmembrane electrochemical proton gradient to facilitate drug transport.

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Autores principales:	Himansha Singh, Saroj Velamakanni, Michael J. Deery, Julie Howard, Shen L. Wei, Hendrik W. van Veen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e06a890869434972a6091c0a35038bd2
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spelling	oai:doaj.org-article:e06a890869434972a6091c0a35038bd22021-12-02T14:39:31ZATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled10.1038/ncomms123872041-1723https://doaj.org/article/e06a890869434972a6091c0a35038bd22016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12387https://doaj.org/toc/2041-1723ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP hydrolysis. Here, the authors show that the bacterial transporter MsbA requires additional energy from the transmembrane electrochemical proton gradient to facilitate drug transport.Himansha SinghSaroj VelamakanniMichael J. DeeryJulie HowardShen L. WeiHendrik W. van VeenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Himansha Singh Saroj Velamakanni Michael J. Deery Julie Howard Shen L. Wei Hendrik W. van Veen ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
description	ABC exporters mediate the translocation of cytotoxic compounds to the cell exterior via ATP hydrolysis. Here, the authors show that the bacterial transporter MsbA requires additional energy from the transmembrane electrochemical proton gradient to facilitate drug transport.
format	article
author	Himansha Singh Saroj Velamakanni Michael J. Deery Julie Howard Shen L. Wei Hendrik W. van Veen
author_facet	Himansha Singh Saroj Velamakanni Michael J. Deery Julie Howard Shen L. Wei Hendrik W. van Veen
author_sort	Himansha Singh
title	ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
title_short	ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
title_full	ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
title_fullStr	ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
title_full_unstemmed	ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
title_sort	atp-dependent substrate transport by the abc transporter msba is proton-coupled
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e06a890869434972a6091c0a35038bd2
work_keys_str_mv	AT himanshasingh atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled AT sarojvelamakanni atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled AT michaeljdeery atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled AT juliehoward atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled AT shenlwei atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled AT hendrikwvanveen atpdependentsubstratetransportbytheabctransportermsbaisprotoncoupled
_version_	1718390623588843520

ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled

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