ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.

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Autores principales:	Tatiana Moiseeva, Brian Hood, Sandy Schamus, Mark J. O’Connor, Thomas P. Conrads, Christopher J. Bakkenist
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e06d11873a0341e4bb21a45631b70175
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spelling	oai:doaj.org-article:e06d11873a0341e4bb21a45631b701752021-12-02T15:38:57ZATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-110.1038/s41467-017-01401-x2041-1723https://doaj.org/article/e06d11873a0341e4bb21a45631b701752017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01401-xhttps://doaj.org/toc/2041-1723ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.Tatiana MoiseevaBrian HoodSandy SchamusMark J. O’ConnorThomas P. ConradsChristopher J. BakkenistNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatiana Moiseeva Brian Hood Sandy Schamus Mark J. O’Connor Thomas P. Conrads Christopher J. Bakkenist ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
description	ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.
format	article
author	Tatiana Moiseeva Brian Hood Sandy Schamus Mark J. O’Connor Thomas P. Conrads Christopher J. Bakkenist
author_facet	Tatiana Moiseeva Brian Hood Sandy Schamus Mark J. O’Connor Thomas P. Conrads Christopher J. Bakkenist
author_sort	Tatiana Moiseeva
title	ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
title_short	ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
title_full	ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
title_fullStr	ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
title_full_unstemmed	ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
title_sort	atr kinase inhibition induces unscheduled origin firing through a cdc7-dependent association between gins and and-1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e06d11873a0341e4bb21a45631b70175
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ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

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