The precise determination of the window of implantation significantly improves ART outcomes

Abstract The human endometrium is receptive to the embryo for a specific period of time known as the window of implantation (WOI). During this period, the endometrium shows a specific gene expression profile suitable for endometrial function evaluation. ER Map is a molecular tool able to accurately...

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Autores principales:	M. Enciso, J. Aizpurua, B. Rodríguez-Estrada, I. Jurado, M. Ferrández-Rives, E. Rodríguez, E. Pérez-Larrea, A. B. Climent, K. Marron, J. Sarasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e06d693f5827474b94a1e094cddc34b4
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spelling	oai:doaj.org-article:e06d693f5827474b94a1e094cddc34b42021-12-02T18:18:59ZThe precise determination of the window of implantation significantly improves ART outcomes10.1038/s41598-021-92955-w2045-2322https://doaj.org/article/e06d693f5827474b94a1e094cddc34b42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92955-whttps://doaj.org/toc/2045-2322Abstract The human endometrium is receptive to the embryo for a specific period of time known as the window of implantation (WOI). During this period, the endometrium shows a specific gene expression profile suitable for endometrial function evaluation. ER Map is a molecular tool able to accurately predict endometrial receptivity status by transcriptomic analysis. In this retrospective study, including 2256 subfertile patients undergoing ART treatment, the clinical value of precise WOI determination is studied in detail. Results obtained when single embryo transfers (sET) were scheduled either within the WOI timeframe as established by ER Map, or deviating from this WOI, are assessed and compared. Data obtained showed that 34.18% (771/2256) of patients had a displaced WOI. Analysis of ART outcomes showed significantly higher pregnancy rates in transfers scheduled within the WOI predicted compared to transfers that deviated more than 12h from this WOI (44.35% vs 23.08%, p < 0.001). The deviation from the WOI had also an impact on the progression of pregnancy, with a significant increase in pregnancy loss (~ twofold) observed in transfers that deviated more than 12h from the WOI predicted. These results indicate that the precise determination of the WOI and personalised embryo transfer can significantly improve clinical outcomes.M. EncisoJ. AizpuruaB. Rodríguez-EstradaI. JuradoM. Ferrández-RivesE. RodríguezE. Pérez-LarreaA. B. ClimentK. MarronJ. SarasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Enciso J. Aizpurua B. Rodríguez-Estrada I. Jurado M. Ferrández-Rives E. Rodríguez E. Pérez-Larrea A. B. Climent K. Marron J. Sarasa The precise determination of the window of implantation significantly improves ART outcomes
description	Abstract The human endometrium is receptive to the embryo for a specific period of time known as the window of implantation (WOI). During this period, the endometrium shows a specific gene expression profile suitable for endometrial function evaluation. ER Map is a molecular tool able to accurately predict endometrial receptivity status by transcriptomic analysis. In this retrospective study, including 2256 subfertile patients undergoing ART treatment, the clinical value of precise WOI determination is studied in detail. Results obtained when single embryo transfers (sET) were scheduled either within the WOI timeframe as established by ER Map, or deviating from this WOI, are assessed and compared. Data obtained showed that 34.18% (771/2256) of patients had a displaced WOI. Analysis of ART outcomes showed significantly higher pregnancy rates in transfers scheduled within the WOI predicted compared to transfers that deviated more than 12h from this WOI (44.35% vs 23.08%, p < 0.001). The deviation from the WOI had also an impact on the progression of pregnancy, with a significant increase in pregnancy loss (~ twofold) observed in transfers that deviated more than 12h from the WOI predicted. These results indicate that the precise determination of the WOI and personalised embryo transfer can significantly improve clinical outcomes.
format	article
author	M. Enciso J. Aizpurua B. Rodríguez-Estrada I. Jurado M. Ferrández-Rives E. Rodríguez E. Pérez-Larrea A. B. Climent K. Marron J. Sarasa
author_facet	M. Enciso J. Aizpurua B. Rodríguez-Estrada I. Jurado M. Ferrández-Rives E. Rodríguez E. Pérez-Larrea A. B. Climent K. Marron J. Sarasa
author_sort	M. Enciso
title	The precise determination of the window of implantation significantly improves ART outcomes
title_short	The precise determination of the window of implantation significantly improves ART outcomes
title_full	The precise determination of the window of implantation significantly improves ART outcomes
title_fullStr	The precise determination of the window of implantation significantly improves ART outcomes
title_full_unstemmed	The precise determination of the window of implantation significantly improves ART outcomes
title_sort	precise determination of the window of implantation significantly improves art outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e06d693f5827474b94a1e094cddc34b4
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The precise determination of the window of implantation significantly improves ART outcomes

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