ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Abstract ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysi...

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Autores principales:	Tao Wu, Xiao-An Ma, Guo-Qing Wang, Qing Li, Miao-Jing Li, Jin-Yue Guo, Xuan Liang, Zhi-Ping Ruan, Tao Tian, Ke-Jun Nan, Li-Na Liu, Hui Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e06dff3a0e9a4247bdae3a23950e9a9f
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spelling	oai:doaj.org-article:e06dff3a0e9a4247bdae3a23950e9a9f2021-12-02T12:30:26ZABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy10.1038/s41598-017-04046-42045-2322https://doaj.org/article/e06dff3a0e9a4247bdae3a23950e9a9f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04046-4https://doaj.org/toc/2045-2322Abstract ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101–1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333–2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210–2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204–1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.Tao WuXiao-An MaGuo-Qing WangQing LiMiao-Jing LiJin-Yue GuoXuan LiangZhi-Ping RuanTao TianKe-Jun NanLi-Na LiuHui GuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tao Wu Xiao-An Ma Guo-Qing Wang Qing Li Miao-Jing Li Jin-Yue Guo Xuan Liang Zhi-Ping Ruan Tao Tian Ke-Jun Nan Li-Na Liu Hui Guo ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
description	Abstract ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101–1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333–2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210–2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204–1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.
format	article
author	Tao Wu Xiao-An Ma Guo-Qing Wang Qing Li Miao-Jing Li Jin-Yue Guo Xuan Liang Zhi-Ping Ruan Tao Tian Ke-Jun Nan Li-Na Liu Hui Guo
author_facet	Tao Wu Xiao-An Ma Guo-Qing Wang Qing Li Miao-Jing Li Jin-Yue Guo Xuan Liang Zhi-Ping Ruan Tao Tian Ke-Jun Nan Li-Na Liu Hui Guo
author_sort	Tao Wu
title	ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
title_short	ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
title_full	ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
title_fullStr	ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
title_full_unstemmed	ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy
title_sort	abo blood type correlates with survival in hepatocellular carcinoma following hepatectomy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e06dff3a0e9a4247bdae3a23950e9a9f
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ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

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