Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus

Multiciliated ependymal cells (ECs) in the mammalian brain are glial cells facilitating cerebral spinal fluid movement. This study describes an inherent cellular plasticity of ECs as maintained by Foxj1 and IKK2 signaling, and shows resulting hydrocephalus when EC de-differentiation is triggered.

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Autores principales:	Khadar Abdi, Chun-Hsiang Lai, Patricia Paez-Gonzalez, Mark Lay, Joon Pyun, Chay T. Kuo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e06e0f558da248d395eeb5256e515254
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spelling	oai:doaj.org-article:e06e0f558da248d395eeb5256e5152542021-12-02T14:41:28ZUncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus10.1038/s41467-018-03812-w2041-1723https://doaj.org/article/e06e0f558da248d395eeb5256e5152542018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03812-whttps://doaj.org/toc/2041-1723Multiciliated ependymal cells (ECs) in the mammalian brain are glial cells facilitating cerebral spinal fluid movement. This study describes an inherent cellular plasticity of ECs as maintained by Foxj1 and IKK2 signaling, and shows resulting hydrocephalus when EC de-differentiation is triggered.Khadar AbdiChun-Hsiang LaiPatricia Paez-GonzalezMark LayJoon PyunChay T. KuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Khadar Abdi Chun-Hsiang Lai Patricia Paez-Gonzalez Mark Lay Joon Pyun Chay T. Kuo Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
description	Multiciliated ependymal cells (ECs) in the mammalian brain are glial cells facilitating cerebral spinal fluid movement. This study describes an inherent cellular plasticity of ECs as maintained by Foxj1 and IKK2 signaling, and shows resulting hydrocephalus when EC de-differentiation is triggered.
format	article
author	Khadar Abdi Chun-Hsiang Lai Patricia Paez-Gonzalez Mark Lay Joon Pyun Chay T. Kuo
author_facet	Khadar Abdi Chun-Hsiang Lai Patricia Paez-Gonzalez Mark Lay Joon Pyun Chay T. Kuo
author_sort	Khadar Abdi
title	Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
title_short	Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
title_full	Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
title_fullStr	Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
title_full_unstemmed	Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
title_sort	uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e06e0f558da248d395eeb5256e515254
work_keys_str_mv	AT khadarabdi uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus AT chunhsianglai uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus AT patriciapaezgonzalez uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus AT marklay uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus AT joonpyun uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus AT chaytkuo uncoveringinherentcellularplasticityofmulticiliatedependymaleadingtoventricularwalltransformationandhydrocephalus
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Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus

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