Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression

Regulatory T-cells (Tregs), known for their immune suppressive function, have been reported in higher numbers, with activated phenotypes and greater potency, in hepatitis B virus (HBV)-related liver diseases than in normal conditions. The numbers, phenotypes, and function of intrahepatic and/or tumo...

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Autores principales:	Wei Li, Jun Han, Hong Wu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e06e751f62564d06b216b2b2d05d167b
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spelling	oai:doaj.org-article:e06e751f62564d06b216b2b2d05d167b2021-12-02T13:25:35ZRegulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression2095-882X10.1016/j.cdtm.2016.09.001https://doaj.org/article/e06e751f62564d06b216b2b2d05d167b2016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300378https://doaj.org/toc/2095-882XRegulatory T-cells (Tregs), known for their immune suppressive function, have been reported in higher numbers, with activated phenotypes and greater potency, in hepatitis B virus (HBV)-related liver diseases than in normal conditions. The numbers, phenotypes, and function of intrahepatic and/or tumor-infiltrating Tregs in HBV-related liver diseases also differ from those of Tregs in the peripheral blood. By inhibiting the function of effector T-cells (Teffs), Tregs play a substantial role in the formation and maintenance of the liver's suppressive microenvironment, which might account for the progression of HBV-related hepatitis and hepatocellular carcinoma (HCC). In acute hepatitis B virus infection, Tregs can safeguard the liver from damage at the cost of prolonged antiviral processes, which results in chronic HBV infection in the liver. Furthermore, Tregs play a role in the development of cirrhosis, the transformation of cirrhosis to HCC, and the progression and metastasis of HCC. Higher levels of Tregs in the peripheral blood and/or tumor sites signify a poorer prognosis in HBV-related liver conditions, and observational data from mouse models and human patients support the theory that depleting Tregs may be therapeutic in HBV-related liver diseases by inducing antiviral and antitumor immunity. Keywords: Regulatory T-cells, Hepatitis B virus, Hepatocellular carcinomaWei LiJun HanHong WuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 2, Pp 67-80 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wei Li Jun Han Hong Wu Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
description	Regulatory T-cells (Tregs), known for their immune suppressive function, have been reported in higher numbers, with activated phenotypes and greater potency, in hepatitis B virus (HBV)-related liver diseases than in normal conditions. The numbers, phenotypes, and function of intrahepatic and/or tumor-infiltrating Tregs in HBV-related liver diseases also differ from those of Tregs in the peripheral blood. By inhibiting the function of effector T-cells (Teffs), Tregs play a substantial role in the formation and maintenance of the liver's suppressive microenvironment, which might account for the progression of HBV-related hepatitis and hepatocellular carcinoma (HCC). In acute hepatitis B virus infection, Tregs can safeguard the liver from damage at the cost of prolonged antiviral processes, which results in chronic HBV infection in the liver. Furthermore, Tregs play a role in the development of cirrhosis, the transformation of cirrhosis to HCC, and the progression and metastasis of HCC. Higher levels of Tregs in the peripheral blood and/or tumor sites signify a poorer prognosis in HBV-related liver conditions, and observational data from mouse models and human patients support the theory that depleting Tregs may be therapeutic in HBV-related liver diseases by inducing antiviral and antitumor immunity. Keywords: Regulatory T-cells, Hepatitis B virus, Hepatocellular carcinoma
format	article
author	Wei Li Jun Han Hong Wu
author_facet	Wei Li Jun Han Hong Wu
author_sort	Wei Li
title	Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
title_short	Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
title_full	Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
title_fullStr	Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
title_full_unstemmed	Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
title_sort	regulatory t-cells promote hepatitis b virus infection and hepatocellular carcinoma progression
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/e06e751f62564d06b216b2b2d05d167b
work_keys_str_mv	AT weili regulatorytcellspromotehepatitisbvirusinfectionandhepatocellularcarcinomaprogression AT junhan regulatorytcellspromotehepatitisbvirusinfectionandhepatocellularcarcinomaprogression AT hongwu regulatorytcellspromotehepatitisbvirusinfectionandhepatocellularcarcinomaprogression
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Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression

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