Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.

<h4>Background</h4>The evidence that red and processed meat influences colorectal carcinogenesis was judged convincing in the 2007 World Cancer Research Fund/American Institute of Cancer Research report. Since then, ten prospective studies have published new results. Here we update the e...

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Autores principales:	Doris S M Chan, Rosa Lau, Dagfinn Aune, Rui Vieira, Darren C Greenwood, Ellen Kampman, Teresa Norat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e077b1a5918244d686166a576496fefa
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spelling	oai:doaj.org-article:e077b1a5918244d686166a576496fefa2021-11-18T06:52:33ZRed and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.1932-620310.1371/journal.pone.0020456https://doaj.org/article/e077b1a5918244d686166a576496fefa2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21674008/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The evidence that red and processed meat influences colorectal carcinogenesis was judged convincing in the 2007 World Cancer Research Fund/American Institute of Cancer Research report. Since then, ten prospective studies have published new results. Here we update the evidence from prospective studies and explore whether there is a non-linear association of red and processed meats with colorectal cancer risk.<h4>Methods and findings</h4>Relevant prospective studies were identified in PubMed until March 2011. For each study, relative risks and 95% confidence intervals (CI) were extracted and pooled with a random-effects model, weighting for the inverse of the variance, in highest versus lowest intake comparison, and dose-response meta-analyses. Red and processed meats intake was associated with increased colorectal cancer risk. The summary relative risk (RR) of colorectal cancer for the highest versus the lowest intake was 1.22 (95% CI = 1.11-1.34) and the RR for every 100 g/day increase was 1.14 (95% CI = 1.04-1.24). Non-linear dose-response meta-analyses revealed that colorectal cancer risk increases approximately linearly with increasing intake of red and processed meats up to approximately 140 g/day, where the curve approaches its plateau. The associations were similar for colon and rectal cancer risk. When analyzed separately, colorectal cancer risk was related to intake of fresh red meat (RR(for 100 g/day increase) = 1.17, 95% CI = 1.05-1.31) and processed meat (RR (for 50 g/day increase) = 1.18, 95% CI = 1.10-1.28). Similar results were observed for colon cancer, but for rectal cancer, no significant associations were observed.<h4>Conclusions</h4>High intake of red and processed meat is associated with significant increased risk of colorectal, colon and rectal cancers. The overall evidence of prospective studies supports limiting red and processed meat consumption as one of the dietary recommendations for the prevention of colorectal cancer.Doris S M ChanRosa LauDagfinn AuneRui VieiraDarren C GreenwoodEllen KampmanTeresa NoratPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20456 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Doris S M Chan Rosa Lau Dagfinn Aune Rui Vieira Darren C Greenwood Ellen Kampman Teresa Norat Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
description	<h4>Background</h4>The evidence that red and processed meat influences colorectal carcinogenesis was judged convincing in the 2007 World Cancer Research Fund/American Institute of Cancer Research report. Since then, ten prospective studies have published new results. Here we update the evidence from prospective studies and explore whether there is a non-linear association of red and processed meats with colorectal cancer risk.<h4>Methods and findings</h4>Relevant prospective studies were identified in PubMed until March 2011. For each study, relative risks and 95% confidence intervals (CI) were extracted and pooled with a random-effects model, weighting for the inverse of the variance, in highest versus lowest intake comparison, and dose-response meta-analyses. Red and processed meats intake was associated with increased colorectal cancer risk. The summary relative risk (RR) of colorectal cancer for the highest versus the lowest intake was 1.22 (95% CI = 1.11-1.34) and the RR for every 100 g/day increase was 1.14 (95% CI = 1.04-1.24). Non-linear dose-response meta-analyses revealed that colorectal cancer risk increases approximately linearly with increasing intake of red and processed meats up to approximately 140 g/day, where the curve approaches its plateau. The associations were similar for colon and rectal cancer risk. When analyzed separately, colorectal cancer risk was related to intake of fresh red meat (RR(for 100 g/day increase) = 1.17, 95% CI = 1.05-1.31) and processed meat (RR (for 50 g/day increase) = 1.18, 95% CI = 1.10-1.28). Similar results were observed for colon cancer, but for rectal cancer, no significant associations were observed.<h4>Conclusions</h4>High intake of red and processed meat is associated with significant increased risk of colorectal, colon and rectal cancers. The overall evidence of prospective studies supports limiting red and processed meat consumption as one of the dietary recommendations for the prevention of colorectal cancer.
format	article
author	Doris S M Chan Rosa Lau Dagfinn Aune Rui Vieira Darren C Greenwood Ellen Kampman Teresa Norat
author_facet	Doris S M Chan Rosa Lau Dagfinn Aune Rui Vieira Darren C Greenwood Ellen Kampman Teresa Norat
author_sort	Doris S M Chan
title	Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
title_short	Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
title_full	Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
title_fullStr	Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
title_full_unstemmed	Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
title_sort	red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e077b1a5918244d686166a576496fefa
work_keys_str_mv	AT dorissmchan redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT rosalau redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT dagfinnaune redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT ruivieira redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT darrencgreenwood redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT ellenkampman redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies AT teresanorat redandprocessedmeatandcolorectalcancerincidencemetaanalysisofprospectivestudies
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Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.

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