Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced order of the thin filaments, their sliding an...

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Autores principales:	Laura Burbaum, Jonathan Schneider, Sarah Scholze, Ralph T. Böttcher, Wolfgang Baumeister, Petra Schwille, Jürgen M. Plitzko, Marion Jasnin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e07d093c4c6e4c35be0d0751adcc87f0
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spelling	oai:doaj.org-article:e07d093c4c6e4c35be0d0751adcc87f02021-12-02T18:19:01ZMolecular-scale visualization of sarcomere contraction within native cardiomyocytes10.1038/s41467-021-24049-02041-1723https://doaj.org/article/e07d093c4c6e4c35be0d0751adcc87f02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24049-0https://doaj.org/toc/2041-1723Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced order of the thin filaments, their sliding and functional states enabling contraction.Laura BurbaumJonathan SchneiderSarah ScholzeRalph T. BöttcherWolfgang BaumeisterPetra SchwilleJürgen M. PlitzkoMarion JasninNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Burbaum Jonathan Schneider Sarah Scholze Ralph T. Böttcher Wolfgang Baumeister Petra Schwille Jürgen M. Plitzko Marion Jasnin Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
description	Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced order of the thin filaments, their sliding and functional states enabling contraction.
format	article
author	Laura Burbaum Jonathan Schneider Sarah Scholze Ralph T. Böttcher Wolfgang Baumeister Petra Schwille Jürgen M. Plitzko Marion Jasnin
author_facet	Laura Burbaum Jonathan Schneider Sarah Scholze Ralph T. Böttcher Wolfgang Baumeister Petra Schwille Jürgen M. Plitzko Marion Jasnin
author_sort	Laura Burbaum
title	Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
title_short	Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
title_full	Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
title_fullStr	Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
title_full_unstemmed	Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
title_sort	molecular-scale visualization of sarcomere contraction within native cardiomyocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e07d093c4c6e4c35be0d0751adcc87f0
work_keys_str_mv	AT lauraburbaum molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT jonathanschneider molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT sarahscholze molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT ralphtbottcher molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT wolfgangbaumeister molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT petraschwille molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT jurgenmplitzko molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes AT marionjasnin molecularscalevisualizationofsarcomerecontractionwithinnativecardiomyocytes
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Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

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