Characterization of genetic subclonal evolution in pancreatic cancer mouse models

In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research o...

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Autores principales:	Noushin Niknafs, Yi Zhong, John Alec Moral, Lance Zhang, Melody Xiaoshan Shao, April Lo, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue, Rachel Karchin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e07d8d5dc22044ab8c8f6ab2bcc5fd75
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spelling	oai:doaj.org-article:e07d8d5dc22044ab8c8f6ab2bcc5fd752021-12-02T17:02:02ZCharacterization of genetic subclonal evolution in pancreatic cancer mouse models10.1038/s41467-019-13100-w2041-1723https://doaj.org/article/e07d8d5dc22044ab8c8f6ab2bcc5fd752019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13100-whttps://doaj.org/toc/2041-1723In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research of tumour evolution.Noushin NiknafsYi ZhongJohn Alec MoralLance ZhangMelody Xiaoshan ShaoApril LoAlvin Makohon-MooreChristine A. Iacobuzio-DonahueRachel KarchinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noushin Niknafs Yi Zhong John Alec Moral Lance Zhang Melody Xiaoshan Shao April Lo Alvin Makohon-Moore Christine A. Iacobuzio-Donahue Rachel Karchin Characterization of genetic subclonal evolution in pancreatic cancer mouse models
description	In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research of tumour evolution.
format	article
author	Noushin Niknafs Yi Zhong John Alec Moral Lance Zhang Melody Xiaoshan Shao April Lo Alvin Makohon-Moore Christine A. Iacobuzio-Donahue Rachel Karchin
author_facet	Noushin Niknafs Yi Zhong John Alec Moral Lance Zhang Melody Xiaoshan Shao April Lo Alvin Makohon-Moore Christine A. Iacobuzio-Donahue Rachel Karchin
author_sort	Noushin Niknafs
title	Characterization of genetic subclonal evolution in pancreatic cancer mouse models
title_short	Characterization of genetic subclonal evolution in pancreatic cancer mouse models
title_full	Characterization of genetic subclonal evolution in pancreatic cancer mouse models
title_fullStr	Characterization of genetic subclonal evolution in pancreatic cancer mouse models
title_full_unstemmed	Characterization of genetic subclonal evolution in pancreatic cancer mouse models
title_sort	characterization of genetic subclonal evolution in pancreatic cancer mouse models
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e07d8d5dc22044ab8c8f6ab2bcc5fd75
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Characterization of genetic subclonal evolution in pancreatic cancer mouse models

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