Characterization of genetic subclonal evolution in pancreatic cancer mouse models
In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research o...
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Auteurs principaux: | Noushin Niknafs, Yi Zhong, John Alec Moral, Lance Zhang, Melody Xiaoshan Shao, April Lo, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue, Rachel Karchin |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
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Sujets: | |
Accès en ligne: | https://doaj.org/article/e07d8d5dc22044ab8c8f6ab2bcc5fd75 |
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