Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods

Takashi Itokawa,1,2 Takashi Suzuki,2,3 Hiroko Iwashita,1 Yuichi Hori1,2 1Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan; 3Ishizuchi Eye Clinic, Niihama, Ehime, JapanCorrespondence...

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Autores principales:	Itokawa T, Suzuki T, Iwashita H, Hori Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	tear film stability wettability tear meniscus height soft contact lens silicone hydrogel lens Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e07e2c2261d04d97bad9f32f4dd3525b
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spelling	oai:doaj.org-article:e07e2c2261d04d97bad9f32f4dd3525b2021-12-02T13:46:22ZComparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods1177-5483https://doaj.org/article/e07e2c2261d04d97bad9f32f4dd3525b2020-12-01T00:00:00Zhttps://www.dovepress.com/comparison-and-evaluation-of-prelens-tear-film-stability-by-different--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Takashi Itokawa,1,2 Takashi Suzuki,2,3 Hiroko Iwashita,1 Yuichi Hori1,2 1Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan; 3Ishizuchi Eye Clinic, Niihama, Ehime, JapanCorrespondence: Takashi SuzukiDepartment of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo 143-8541, JapanTel +81-3-3762-4151Fax +81-3-3298-0030Email t-suzuki@ishizuchi-eye-clinic.jpPurpose: Prelens tear film stability of soft contact lens (SCL) play an important role for contact lens discomfort. In this study, we investigated the association between two types of noninvasive methods and evaluated the tear film stability with SCL using the methods.Patients and Methods: In experiment 1, images of ring mire were recorded with a keratograph after focusing the pigment located at the front or back of the SCL. Interferometry and videokeratoscopy were used for the assessment of tear film stability in the right eye of 10 women, with two different cosmetic daily disposable SCLs: polymacon and etafilcon A with polyvinylpyrrolidone. Time to first distortion by noninvasive keratograph break up time (NIKBUT-first) was compared to noninvasive interferometry break up time (NIBUT). In experiment 2, ten normal females wore two different daily disposable SCLs: samfilcon A and narafilcon A. NIKBUT-first and NIBUT were compared between the lenses after 8 hours of SCL wearing.Results: In experiment 1, NIBUT-first without SCL was significantly correlated to NIBUT without SCL (r=0.445, P=0.0488, Pearson’s correlation coefficients). However, NIKBUT-first with SCL was not significantly correlated with NIBUT with SCL. In experiment 2, although NIKBUT-first was not significantly different between SCLs, samfilcon A had significantly longer NIBUT than narafilcon A (P=0.0315, paired t-test).Conclusion: NIKBUT-first with SCL could be related to tear film stability between the lens and the corneal surface, but not to prelens tear film stability. NIIBUT could be a suitable method to evaluate prelens tear stability.Keywords: tear film stability, wettability, tear meniscus height, soft contact lens, silicone hydrogel lensItokawa TSuzuki TIwashita HHori YDove Medical Pressarticletear film stabilitywettabilitytear meniscus heightsoft contact lenssilicone hydrogel lensOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4459-4468 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tear film stability wettability tear meniscus height soft contact lens silicone hydrogel lens Ophthalmology RE1-994
spellingShingle	tear film stability wettability tear meniscus height soft contact lens silicone hydrogel lens Ophthalmology RE1-994 Itokawa T Suzuki T Iwashita H Hori Y Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
description	Takashi Itokawa,1,2 Takashi Suzuki,2,3 Hiroko Iwashita,1 Yuichi Hori1,2 1Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan; 3Ishizuchi Eye Clinic, Niihama, Ehime, JapanCorrespondence: Takashi SuzukiDepartment of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo 143-8541, JapanTel +81-3-3762-4151Fax +81-3-3298-0030Email t-suzuki@ishizuchi-eye-clinic.jpPurpose: Prelens tear film stability of soft contact lens (SCL) play an important role for contact lens discomfort. In this study, we investigated the association between two types of noninvasive methods and evaluated the tear film stability with SCL using the methods.Patients and Methods: In experiment 1, images of ring mire were recorded with a keratograph after focusing the pigment located at the front or back of the SCL. Interferometry and videokeratoscopy were used for the assessment of tear film stability in the right eye of 10 women, with two different cosmetic daily disposable SCLs: polymacon and etafilcon A with polyvinylpyrrolidone. Time to first distortion by noninvasive keratograph break up time (NIKBUT-first) was compared to noninvasive interferometry break up time (NIBUT). In experiment 2, ten normal females wore two different daily disposable SCLs: samfilcon A and narafilcon A. NIKBUT-first and NIBUT were compared between the lenses after 8 hours of SCL wearing.Results: In experiment 1, NIBUT-first without SCL was significantly correlated to NIBUT without SCL (r=0.445, P=0.0488, Pearson’s correlation coefficients). However, NIKBUT-first with SCL was not significantly correlated with NIBUT with SCL. In experiment 2, although NIKBUT-first was not significantly different between SCLs, samfilcon A had significantly longer NIBUT than narafilcon A (P=0.0315, paired t-test).Conclusion: NIKBUT-first with SCL could be related to tear film stability between the lens and the corneal surface, but not to prelens tear film stability. NIIBUT could be a suitable method to evaluate prelens tear stability.Keywords: tear film stability, wettability, tear meniscus height, soft contact lens, silicone hydrogel lens
format	article
author	Itokawa T Suzuki T Iwashita H Hori Y
author_facet	Itokawa T Suzuki T Iwashita H Hori Y
author_sort	Itokawa T
title	Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
title_short	Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
title_full	Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
title_fullStr	Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
title_full_unstemmed	Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods
title_sort	comparison and evaluation of prelens tear film stability by different noninvasive in vivo methods
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e07e2c2261d04d97bad9f32f4dd3525b
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_version_	1718392529168105472

Comparison and Evaluation of Prelens Tear Film Stability by Different Noninvasive in vivo Methods

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